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Differential Suppression of Heat-Killed Lactobacilli Isolated from kimchi, a Korean Traditional Food, on Airway Hyper-responsiveness in Mice

Authors
Hong, Hye-JinKim, EugeneCho, DaehoKim, Tae Sung
Issue Date
May-2010
Publisher
SPRINGER/PLENUM PUBLISHERS
Keywords
Kimchi; asthma; tolerance; mice
Citation
JOURNAL OF CLINICAL IMMUNOLOGY, v.30, no.3, pp.449 - 458
Journal Title
JOURNAL OF CLINICAL IMMUNOLOGY
Volume
30
Number
3
Start Page
449
End Page
458
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13218
DOI
10.1007/s10875-010-9375-8
ISSN
0271-9142
Abstract
Probiotics have been shown to be effective in reducing allergic symptoms. However, there are few studies to evaluate the therapeutic effects of lactobacilli on allergen-induced airway inflammation. We investigated whether three heat-killed lactobacilli, Lactobacillus plantarum, Lactobacillus curvatus and Lactobacillus sakei subsp. sakei, isolated from kimchi, exerted inhibitory effects on airway hyper-responsiveness in a murine asthma model. Heat-killed lactic acid bacteria were orally administered into BALB/c mice, followed by challenge with aerosolized ovalbumin, after which allergic symptoms were evaluated. Airway inflammation was suppressed in the L. plantarum- and L. curvatus-treated mice. Interleukin (IL)-4 and IL-5 levels were significantly lower in the L. plantarum- and L. curvatus-treated mice than in those treated with L. sakei subsp. sakei. Importantly, heat-killed L. plantarum administration induced Foxp3 expression in intestinal lamina propria cells, and heat-killed L. curvatus induced IL-10 as a way of inducing tolerance. Specific strains of lactobacilli isolated from kimchi can effectively suppress airway hyper-responsiveness.
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