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Proteomic analysis of time-dependant difference of protein expression profile changes during neuronal differentiation of mouse embryonic stem cells

Authors
Shim, Jung HeeCho, Sun A.Seo, Min JiKim, Jung HeeRyu, Na KyungYoo, Kyung HyunYang, Moon HeeKim, SeyoonBahk, Young YilPark, Jong Hoon
Issue Date
Mar-2010
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Keywords
2-DE; Differentiation; ES cell; Neuronal; Proteomic analysis
Citation
MOLECULES AND CELLS, v.29, no.3, pp.239 - 244
Journal Title
MOLECULES AND CELLS
Volume
29
Number
3
Start Page
239
End Page
244
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13253
DOI
10.1007/s10059-010-0022-2
ISSN
1016-8478
Abstract
The study of ES cell-mediated neuronal differentiation allows elucidating the mechanism of neuronal development in spite of the complexity and the difficult accessibility. During the differentiation of embryonic stem cells into neuronal cell, the expression profiles in the level of protein were extensively investigated by proteomic analysis. These cells were analyzed for charges in proteome during the differentiation of ES cells by 2-dimensional electrophoresis (2-DE) and MALDI-TOF MS. Seven unique proteins were identified, some of which were differentially expressed at each stage. A complex system of neuronal differentiation can be activated in cultured embryonic stem cells and our two dimensional electrophoresis data should be useful for investigating some of the mechanism that regulates neuronal differentiation.
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