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Assessment of the Anti-angiogenic, Anti-inflammatory and Antinociceptive Properties of Ethyl Vanillin

Authors
Jung, Hyun-JooSong, Yun SeonKim, KyunghoonLim, Chang-JinPark, Eun-Hee
Issue Date
Feb-2010
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Anti-angiogenic; Anti-inflammatory; Antinociceptive; Ethyl vanillin; Nitric oxide; Reactive oxygen species
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.33, no.2, pp.309 - 316
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
33
Number
2
Start Page
309
End Page
316
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13277
DOI
10.1007/s12272-010-0217-2
ISSN
0253-6269
Abstract
The present work aimed to assess novel pharmacological properties of ethyl vanillin (EVA) which is used as a flavoring agent for cakes, dessert, confectionary, etc. EVA exhibited an inhibitory activity in the chorioallantoic membrane angiogenesis. Anti-inflammatory activity of EVA was convinced using the two in vivo models, such as vascular permeability and air pouch models in mice. Antinociceptive activity of EVA was assessed using acetic acid-induced writhing model in mice. EVA suppressed production of nitric oxide and induction of inducible nitric oxide synthase in the lipopolysaccharide (LPS)-activated RAW264.7 macrophage cells. However, EVA could not suppress induction of cyclooxygenase-2 in the LPS-activated macrophages. EVA diminished reactive oxygen species level in the LPS-activated macrophages. EVA also suppressed enhanced matrix metalloproteinase-9 gelatinolytic activity in the LPS-activated RAW264.7 macrophage cells. EVA at the used concentrations couldn't diminish viability of the macrophage cells. Taken together, the anti-angiogenic, anti-inflammatory and anti-nociceptive properties of EVA are based on its suppressive effect on the production of nitric oxide possibly via decreasing the reactive oxygen species level.
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