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Design and Synthesis of 3 '-Fluoropenciclovir Analogues as Antiviral Agents
- Authors
- Choi, Myung-Hee; Lee, Chong-Kyo; Kim, Hee-Doo
- Issue Date
- Feb-2010
- Publisher
- PHARMACEUTICAL SOC KOREA
- Keywords
- Antiviral; Fluorine switch; Penciclovir; 3 '-Fluoropenciclovir
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.33, no.2, pp 197 - 202
- Pages
- 6
- Journal Title
- ARCHIVES OF PHARMACAL RESEARCH
- Volume
- 33
- Number
- 2
- Start Page
- 197
- End Page
- 202
- ISSN
- 0253-6269
1976-3786
- Abstract
- Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized X-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
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