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Design and Synthesis of 3 '-Fluoropenciclovir Analogues as Antiviral Agents

Authors
Choi, Myung-HeeLee, Chong-KyoKim, Hee-Doo
Issue Date
Feb-2010
Publisher
PHARMACEUTICAL SOC KOREA
Keywords
Antiviral; Fluorine switch; Penciclovir; 3 ' -Fluoropenciclovir
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.33, no.2, pp.197 - 202
Journal Title
ARCHIVES OF PHARMACAL RESEARCH
Volume
33
Number
2
Start Page
197
End Page
202
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13278
DOI
10.1007/s12272-010-0202-9
ISSN
0253-6269
Abstract
Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized X-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
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