Design and Synthesis of 3 '-Fluoropenciclovir Analogues as Antiviral Agents
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Myung-Hee | - |
dc.contributor.author | Lee, Chong-Kyo | - |
dc.contributor.author | Kim, Hee-Doo | - |
dc.date.available | 2021-02-22T13:48:48Z | - |
dc.date.issued | 2010-02 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13278 | - |
dc.description.abstract | Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized X-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Design and Synthesis of 3 '-Fluoropenciclovir Analogues as Antiviral Agents | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s12272-010-0202-9 | - |
dc.identifier.scopusid | 2-s2.0-77949908366 | - |
dc.identifier.wosid | 000274919600004 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.33, no.2, pp 197 - 202 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 33 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 197 | - |
dc.citation.endPage | 202 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001419546 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | OPEN-CHAIN ANALOGS | - |
dc.subject.keywordPlus | NUCLEOSIDES | - |
dc.subject.keywordPlus | NEPLANOCIN | - |
dc.subject.keywordAuthor | Antiviral | - |
dc.subject.keywordAuthor | Fluorine switch | - |
dc.subject.keywordAuthor | Penciclovir | - |
dc.subject.keywordAuthor | 3 '-Fluoropenciclovir | - |
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