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Design and Synthesis of 3 '-Fluoropenciclovir Analogues as Antiviral Agents

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dc.contributor.authorChoi, Myung-Hee-
dc.contributor.authorLee, Chong-Kyo-
dc.contributor.authorKim, Hee-Doo-
dc.date.available2021-02-22T13:48:48Z-
dc.date.issued2010-02-
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13278-
dc.description.abstractBased on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized X-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.-
dc.format.extent6-
dc.language영어-
dc.language.isoENG-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.titleDesign and Synthesis of 3 '-Fluoropenciclovir Analogues as Antiviral Agents-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.1007/s12272-010-0202-9-
dc.identifier.scopusid2-s2.0-77949908366-
dc.identifier.wosid000274919600004-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.33, no.2, pp 197 - 202-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume33-
dc.citation.number2-
dc.citation.startPage197-
dc.citation.endPage202-
dc.type.docTypeArticle-
dc.identifier.kciidART001419546-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusOPEN-CHAIN ANALOGS-
dc.subject.keywordPlusNUCLEOSIDES-
dc.subject.keywordPlusNEPLANOCIN-
dc.subject.keywordAuthorAntiviral-
dc.subject.keywordAuthorFluorine switch-
dc.subject.keywordAuthorPenciclovir-
dc.subject.keywordAuthor3 '-Fluoropenciclovir-
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