Carabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappa B alpha degradation in RAW 264.7 cells
DC Field | Value | Language |
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dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Lim, Hyo Jin | - |
dc.contributor.author | Lee, Da Yeon | - |
dc.contributor.author | Jung, Hyeyoun | - |
dc.contributor.author | Kim, Mi-Ran | - |
dc.contributor.author | Moon, Dong-Cheul | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T13:48:58Z | - |
dc.date.issued | 2010-01 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.issn | 1090-2104 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13291 | - |
dc.description.abstract | Carabrol, isolated from Carpesium macrocephalum, showed anti-inflammatory potential in LPS-induced RAW 264.7 murine macrophages. In present study, carabrol demonstrated the inhibitory activity on pro-inflammatory cytokines such as IL-1 beta, IL-6 and TNF-alpha. In addition, mRNA and protein levels of iNOS and COX-2 were reduced by carabrol. Molecular analysis revealed that these suppressive effects were correlated with the inactivation of p38 and JNK via inhibition of NF-kappa B activation. Immunoblotting showed that carabrol suppressed LPS-induced degradation of I-kappa B alpha and decreased nuclear translocation of p65. Taken together, these results suggest that carabrol can be a modulator of pro-inflammatory signal transduction pathway in RAW 264.7 cells. (C) 2009 Elsevier Inc. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.title | Carabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappa B alpha degradation in RAW 264.7 cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.bbrc.2009.12.073 | - |
dc.identifier.scopusid | 2-s2.0-73949151097 | - |
dc.identifier.wosid | 000274097800019 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.391, no.3, pp 1400 - 1404 | - |
dc.citation.title | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.citation.volume | 391 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1400 | - |
dc.citation.endPage | 1404 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biophysics | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biophysics | - |
dc.subject.keywordPlus | ACTIVATED PROTEIN-KINASE | - |
dc.subject.keywordPlus | MACROPHAGES | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | INOS | - |
dc.subject.keywordPlus | ERK | - |
dc.subject.keywordPlus | CYCLOOXYGENASE | - |
dc.subject.keywordPlus | BIOSYNTHESIS | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordAuthor | Carabrol | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | Prostaglandin E-2 | - |
dc.subject.keywordAuthor | Carpesium macrocephalum | - |
dc.subject.keywordAuthor | Nuclear factor-kappa B | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/abs/pii/S0006291X09024462?via%3Dihub | - |
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