Detailed Information

Cited 0 time in webofscience Cited 26 time in scopus
Metadata Downloads

Carabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappa B alpha degradation in RAW 264.7 cells

Full metadata record
DC FieldValueLanguage
dc.contributor.authorLee, Hwa Jin-
dc.contributor.authorLim, Hyo Jin-
dc.contributor.authorLee, Da Yeon-
dc.contributor.authorJung, Hyeyoun-
dc.contributor.authorKim, Mi-Ran-
dc.contributor.authorMoon, Dong-Cheul-
dc.contributor.authorKim, Keun Il-
dc.contributor.authorLee, Myeong-Sok-
dc.contributor.authorRyu, Jae-Ha-
dc.date.available2021-02-22T13:48:58Z-
dc.date.issued2010-01-
dc.identifier.issn0006-291X-
dc.identifier.issn1090-2104-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13291-
dc.description.abstractCarabrol, isolated from Carpesium macrocephalum, showed anti-inflammatory potential in LPS-induced RAW 264.7 murine macrophages. In present study, carabrol demonstrated the inhibitory activity on pro-inflammatory cytokines such as IL-1 beta, IL-6 and TNF-alpha. In addition, mRNA and protein levels of iNOS and COX-2 were reduced by carabrol. Molecular analysis revealed that these suppressive effects were correlated with the inactivation of p38 and JNK via inhibition of NF-kappa B activation. Immunoblotting showed that carabrol suppressed LPS-induced degradation of I-kappa B alpha and decreased nuclear translocation of p65. Taken together, these results suggest that carabrol can be a modulator of pro-inflammatory signal transduction pathway in RAW 264.7 cells. (C) 2009 Elsevier Inc. All rights reserved.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.titleCarabrol suppresses LPS-induced nitric oxide synthase expression by inactivation of p38 and JNK via inhibition of I-kappa B alpha degradation in RAW 264.7 cells-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1016/j.bbrc.2009.12.073-
dc.identifier.scopusid2-s2.0-73949151097-
dc.identifier.wosid000274097800019-
dc.identifier.bibliographicCitationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.391, no.3, pp 1400 - 1404-
dc.citation.titleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.citation.volume391-
dc.citation.number3-
dc.citation.startPage1400-
dc.citation.endPage1404-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiophysics-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiophysics-
dc.subject.keywordPlusACTIVATED PROTEIN-KINASE-
dc.subject.keywordPlusMACROPHAGES-
dc.subject.keywordPlusLIPOPOLYSACCHARIDE-
dc.subject.keywordPlusINFLAMMATION-
dc.subject.keywordPlusPATHWAY-
dc.subject.keywordPlusINOS-
dc.subject.keywordPlusERK-
dc.subject.keywordPlusCYCLOOXYGENASE-
dc.subject.keywordPlusBIOSYNTHESIS-
dc.subject.keywordPlusINDUCTION-
dc.subject.keywordAuthorCarabrol-
dc.subject.keywordAuthorNitric oxide-
dc.subject.keywordAuthorProstaglandin E-2-
dc.subject.keywordAuthorCarpesium macrocephalum-
dc.subject.keywordAuthorNuclear factor-kappa B-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/abs/pii/S0006291X09024462?via%3Dihub-
Files in This Item
Go to Link
Appears in
Collections
약학대학 > 약학부 > 1. Journal Articles
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Keun Il photo

Kim, Keun Il
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE