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L-형 칼슘 이온통로에 의한 파골세포 분화의 조절The Regulation of Osteoclastogenesis by L-Type Channel Agonist
- Other Titles
- The Regulation of Osteoclastogenesis by L-Type Channel Agonist
- Issue Date
- Dec-2010
- Publisher
- 대한약학회
- Keywords
- L-type Ca2+ channel; osteoclast; NFATc1; ERK; p38
- Citation
- 약 학 회 지, v.54, no.6, pp 461 - 465
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 54
- Number
- 6
- Start Page
- 461
- End Page
- 465
- ISSN
- 0377-9556
- Abstract
- We investigated the role of L-type Ca2+ channel in receptor activator of nuclear factor-kappaB ligand (RANKL)-induced osteoclast formation. BayK 8644, a L-type Ca2+ channel agonist, was shown to increase the RANKLinduced osteoclastogenesis and actin ring formation in mouse bone marrow-dereived macrophage (BMM) culture system. BayK 8644 stimulated RANKL-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation, which leads to increased nuclear factor of activated T cells (NFAT)c1 expression. Taken together, these data indicate that L-type Ca2+ channel regulates osteoclast formation possibly through ERK- and p38-mediated NFATc1 expression.
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