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조골세포내 PDE4에 의한 PTH 신호의 음성적 조절The Negative Role of PDE4 on PTH-induced Signaling in Osteoblasts

Other Titles
The Negative Role of PDE4 on PTH-induced Signaling in Osteoblasts
Authors
박효정노아롱새미이정민임미정
Issue Date
Oct-2010
Publisher
대한약학회
Keywords
PTH; PDE4; osteoblast; osteoclast
Citation
약 학 회 지, v.54, no.5, pp 410 - 415
Pages
6
Journal Title
약 학 회 지
Volume
54
Number
5
Start Page
410
End Page
415
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13402
ISSN
0377-9556
Abstract
We explored the role of phosphodiesterase 4 (PDE4) on parathyroid (PTH)-induced signaling in osteoblasts. PTH was shown to increase the activity of PDE, mainly PDE4, in osteoblasts, which is partly attributable to elevated PDE4B and PDE4D mRNA expression. The use of PDE4 inhibitor strengthened the PTH-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation. Furthermore, the PDE4 inhibitor stimulated PTH-induced receptor activator of nuclear factor-κB ligand (RANKL) expression in osteoblasts, which in turn increased osteoclast formation. Taken together, these data suggest the negative role of PDE4 on PTH-induced signaling in osteoblasts.
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