조골세포내 PDE4에 의한 PTH 신호의 음성적 조절The Negative Role of PDE4 on PTH-induced Signaling in Osteoblasts
- Other Titles
- The Negative Role of PDE4 on PTH-induced Signaling in Osteoblasts
- Authors
- 박효정; 노아롱새미; 이정민; 임미정
- Issue Date
- Oct-2010
- Publisher
- 대한약학회
- Keywords
- PTH; PDE4; osteoblast; osteoclast
- Citation
- 약 학 회 지, v.54, no.5, pp 410 - 415
- Pages
- 6
- Journal Title
- 약 학 회 지
- Volume
- 54
- Number
- 5
- Start Page
- 410
- End Page
- 415
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13402
- ISSN
- 0377-9556
- Abstract
- We explored the role of phosphodiesterase 4 (PDE4) on parathyroid (PTH)-induced signaling in osteoblasts. PTH was shown to increase the activity of PDE, mainly PDE4, in osteoblasts, which is partly attributable to elevated PDE4B and PDE4D mRNA expression. The use of PDE4 inhibitor strengthened the PTH-induced extracellular signal-regulated kinase (ERK) and p38 MAP kinase (MAPK) activation. Furthermore, the PDE4 inhibitor stimulated PTH-induced receptor activator of nuclear factor-κB ligand (RANKL) expression in osteoblasts, which in turn increased osteoclast formation.
Taken together, these data suggest the negative role of PDE4 on PTH-induced signaling in osteoblasts.
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