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ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES

Authors
Lee, S. H.Kim, K-YRyu, S. Y.Yoon, Y.Hahm, D-HKang, S. A.Cho, S. H.Lim, J-SMoon, E-YYoon, S. R.Lee, H. G.Yoon, D. Y.Yang, Y.
Issue Date
Jan-2010
Publisher
C M B ASSOC
Keywords
C/EBP alpha; PPAR gamma; Adiponectin; Asarone; Hormone-sensitive lipase
Citation
CELLULAR AND MOLECULAR BIOLOGY, v.56, pp.OL1215 - OL1222
Journal Title
CELLULAR AND MOLECULAR BIOLOGY
Volume
56
Start Page
OL1215
End Page
OL1222
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13593
DOI
10.1170/138
ISSN
0145-5680
Abstract
Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-alpha and peroxisome proliferator activated receptor-gamma, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPAR gamma and C/EBP alpha and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.
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