ASARONE INHIBITS ADIPOGENESIS AND STIMULATES LIPOLYSIS IN 3T3-L1 ADIPOCYTES
- Lee, S. H.; Kim, K-Y; Ryu, S. Y.; Yoon, Y.; Hahm, D-H; Kang, S. A.; Cho, S. H.; Lim, J-S; Moon, E-Y; Yoon, S. R.; Lee, H. G.; Yoon, D. Y.; Yang, Y.
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- C M B ASSOC
- C/EBP alpha; PPAR gamma; Adiponectin; Asarone; Hormone-sensitive lipase
- CELLULAR AND MOLECULAR BIOLOGY, v.56, pp.OL1215 - OL1222
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- CELLULAR AND MOLECULAR BIOLOGY
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- Asarone is a molecule found in certain plants such as Acorus calamus, the root of which is used in traditional medicine to treat diabetes. We determined the molecular mechanism underlying the anti-diabetic activity of asarone. Treatment of asarone significantly inhibited the differentiation of 3T3-L1 preadipocytes through suppression of expression of the transcription factors, CCAAT/enhancer binding protein-alpha and peroxisome proliferator activated receptor-gamma, which activate adipogenesis. Intracellular triglyceride levels were reduced by asarone in a dose-dependent manner and asarone treatment stimulated the phosphorylation of hormone-sensitive lipase. Together, the present findings indicate that asarone inhibits adipogenesis by down-regulation of PPAR gamma and C/EBP alpha and reduces lipid accumulation by stimulation of lipolysis through an increase in hormone-sensitive lipase activity.
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