Immunity to Trop-1, a newly identified breast cancer antigen, inhibits the growth of breast cancer in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Byeong C. | - |
dc.contributor.author | Jung, Mi Y. | - |
dc.contributor.author | Cho, Daeho | - |
dc.contributor.author | O-Sullivan, InSug | - |
dc.contributor.author | Cohen, Edward P. | - |
dc.contributor.author | Kim, Tae Sung | - |
dc.date.available | 2021-02-22T14:03:00Z | - |
dc.date.issued | 2010-11 | - |
dc.identifier.issn | 0264-410X | - |
dc.identifier.issn | 1358-8745 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13607 | - |
dc.description.abstract | This study describes the immunotherapeutic properties of vaccines that encode tumor-associated calcium signal transducer-1 (Trop-1), a newly identified breast cancer antigen, in mice with breast cancer. Previously we found that Trop-1 was over-expressed in cellular breast cancer vaccines that were highly enriched for cells that induced therapeutic CTL-mediated immune responses in mice with breast cancer, as compared with non-enriched vaccines. In this study, to determine if the expression of Trop-1 by cells in the enriched vaccine was responsible for its therapeutic benefits, an expression plasmid that specified the Trop-1 gene was transfected into the LM fibroblast cells, which was then used as a vaccine. To augment their immunogenic properties, the fibroblasts were genetically modified before Trop-1 DNA-transfer to secrete IL-2 and to express allogeneic MHC class I H-2Kb-determinants. Mice with established breast cancer treated solely by immunization with fibroblasts modified to express Trop-1 developed CD8+ cell-mediated immunity to the breast cancer cells. The immunity was sufficient to prolong the survival of mice with established breast cancer. In some instances, the immunity was sufficient to result in rejection of the tumor; the mice remained tumor free more than 60 days. © 2010 Elsevier Ltd. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier | - |
dc.title | Immunity to Trop-1, a newly identified breast cancer antigen, inhibits the growth of breast cancer in mice | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.vaccine.2010.09.057 | - |
dc.identifier.scopusid | 2-s2.0-78349310570 | - |
dc.identifier.wosid | 000285526300008 | - |
dc.identifier.bibliographicCitation | Vaccine, v.28, no.49, pp 7757 - 7763 | - |
dc.citation.title | Vaccine | - |
dc.citation.volume | 28 | - |
dc.citation.number | 49 | - |
dc.citation.startPage | 7757 | - |
dc.citation.endPage | 7763 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordPlus | cancer vaccine | - |
dc.subject.keywordPlus | interleukin 2 | - |
dc.subject.keywordPlus | major histocompatibility antigen class 1 | - |
dc.subject.keywordPlus | plasmid vector | - |
dc.subject.keywordPlus | tumor antigen | - |
dc.subject.keywordPlus | tumor associated calcium signal transducer 1 | - |
dc.subject.keywordPlus | unclassified drug | - |
dc.subject.keywordPlus | animal cell | - |
dc.subject.keywordPlus | antigen expression | - |
dc.subject.keywordPlus | article | - |
dc.subject.keywordPlus | breast adenocarcinoma | - |
dc.subject.keywordPlus | cancer immunization | - |
dc.subject.keywordPlus | cancer inhibition | - |
dc.subject.keywordPlus | cancer survival | - |
dc.subject.keywordPlus | cellular immunity | - |
dc.subject.keywordPlus | controlled study | - |
dc.subject.keywordPlus | cytotoxic T lymphocyte | - |
dc.subject.keywordPlus | DNA modification | - |
dc.subject.keywordPlus | DNA transfer | - |
dc.subject.keywordPlus | fibroblast | - |
dc.subject.keywordPlus | genetic transcription | - |
dc.subject.keywordPlus | graft rejection | - |
dc.subject.keywordPlus | immune response | - |
dc.subject.keywordPlus | mouse | - |
dc.subject.keywordPlus | nonhuman | - |
dc.subject.keywordPlus | plasmid | - |
dc.subject.keywordPlus | priority journal | - |
dc.subject.keywordPlus | tumor immunity | - |
dc.subject.keywordPlus | Animals | - |
dc.subject.keywordPlus | Antigens, Neoplasm | - |
dc.subject.keywordPlus | Cancer Vaccines | - |
dc.subject.keywordPlus | Cell Adhesion Molecules | - |
dc.subject.keywordPlus | Cell Line | - |
dc.subject.keywordPlus | Female | - |
dc.subject.keywordPlus | Fibroblasts | - |
dc.subject.keywordPlus | H-2 Antigens | - |
dc.subject.keywordPlus | Immunity, Cellular | - |
dc.subject.keywordPlus | Interleukin-2 | - |
dc.subject.keywordPlus | Mammary Neoplasms, Experimental | - |
dc.subject.keywordPlus | Mice | - |
dc.subject.keywordPlus | Mice, Inbred C3H | - |
dc.subject.keywordPlus | Plasmids | - |
dc.subject.keywordPlus | Spleen | - |
dc.subject.keywordPlus | T-Lymphocytes, Cytotoxic | - |
dc.subject.keywordPlus | Transfection | - |
dc.subject.keywordAuthor | Breast cancer | - |
dc.subject.keywordAuthor | Immunity | - |
dc.subject.keywordAuthor | Trop-1 | - |
dc.subject.keywordAuthor | Tumor antigen | - |
dc.subject.keywordAuthor | Vaccination | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Sookmyung Women's University. Cheongpa-ro 47-gil 100 (Cheongpa-dong 2ga), Yongsan-gu, Seoul, 04310, Korea02-710-9127
Copyright©Sookmyung Women's University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.