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Immunity to Trop-1, a newly identified breast cancer antigen, inhibits the growth of breast cancer in mice

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dc.contributor.authorLee, Byeong C.-
dc.contributor.authorJung, Mi Y.-
dc.contributor.authorCho, Daeho-
dc.contributor.authorO-Sullivan, InSug-
dc.contributor.authorCohen, Edward P.-
dc.contributor.authorKim, Tae Sung-
dc.date.available2021-02-22T14:03:00Z-
dc.date.issued2010-11-
dc.identifier.issn0264-410X-
dc.identifier.issn1358-8745-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13607-
dc.description.abstractThis study describes the immunotherapeutic properties of vaccines that encode tumor-associated calcium signal transducer-1 (Trop-1), a newly identified breast cancer antigen, in mice with breast cancer. Previously we found that Trop-1 was over-expressed in cellular breast cancer vaccines that were highly enriched for cells that induced therapeutic CTL-mediated immune responses in mice with breast cancer, as compared with non-enriched vaccines. In this study, to determine if the expression of Trop-1 by cells in the enriched vaccine was responsible for its therapeutic benefits, an expression plasmid that specified the Trop-1 gene was transfected into the LM fibroblast cells, which was then used as a vaccine. To augment their immunogenic properties, the fibroblasts were genetically modified before Trop-1 DNA-transfer to secrete IL-2 and to express allogeneic MHC class I H-2Kb-determinants. Mice with established breast cancer treated solely by immunization with fibroblasts modified to express Trop-1 developed CD8+ cell-mediated immunity to the breast cancer cells. The immunity was sufficient to prolong the survival of mice with established breast cancer. In some instances, the immunity was sufficient to result in rejection of the tumor; the mice remained tumor free more than 60 days. © 2010 Elsevier Ltd.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherElsevier-
dc.titleImmunity to Trop-1, a newly identified breast cancer antigen, inhibits the growth of breast cancer in mice-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.vaccine.2010.09.057-
dc.identifier.scopusid2-s2.0-78349310570-
dc.identifier.wosid000285526300008-
dc.identifier.bibliographicCitationVaccine, v.28, no.49, pp 7757 - 7763-
dc.citation.titleVaccine-
dc.citation.volume28-
dc.citation.number49-
dc.citation.startPage7757-
dc.citation.endPage7763-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.subject.keywordPluscancer vaccine-
dc.subject.keywordPlusinterleukin 2-
dc.subject.keywordPlusmajor histocompatibility antigen class 1-
dc.subject.keywordPlusplasmid vector-
dc.subject.keywordPlustumor antigen-
dc.subject.keywordPlustumor associated calcium signal transducer 1-
dc.subject.keywordPlusunclassified drug-
dc.subject.keywordPlusanimal cell-
dc.subject.keywordPlusantigen expression-
dc.subject.keywordPlusarticle-
dc.subject.keywordPlusbreast adenocarcinoma-
dc.subject.keywordPluscancer immunization-
dc.subject.keywordPluscancer inhibition-
dc.subject.keywordPluscancer survival-
dc.subject.keywordPluscellular immunity-
dc.subject.keywordPluscontrolled study-
dc.subject.keywordPluscytotoxic T lymphocyte-
dc.subject.keywordPlusDNA modification-
dc.subject.keywordPlusDNA transfer-
dc.subject.keywordPlusfibroblast-
dc.subject.keywordPlusgenetic transcription-
dc.subject.keywordPlusgraft rejection-
dc.subject.keywordPlusimmune response-
dc.subject.keywordPlusmouse-
dc.subject.keywordPlusnonhuman-
dc.subject.keywordPlusplasmid-
dc.subject.keywordPluspriority journal-
dc.subject.keywordPlustumor immunity-
dc.subject.keywordPlusAnimals-
dc.subject.keywordPlusAntigens, Neoplasm-
dc.subject.keywordPlusCancer Vaccines-
dc.subject.keywordPlusCell Adhesion Molecules-
dc.subject.keywordPlusCell Line-
dc.subject.keywordPlusFemale-
dc.subject.keywordPlusFibroblasts-
dc.subject.keywordPlusH-2 Antigens-
dc.subject.keywordPlusImmunity, Cellular-
dc.subject.keywordPlusInterleukin-2-
dc.subject.keywordPlusMammary Neoplasms, Experimental-
dc.subject.keywordPlusMice-
dc.subject.keywordPlusMice, Inbred C3H-
dc.subject.keywordPlusPlasmids-
dc.subject.keywordPlusSpleen-
dc.subject.keywordPlusT-Lymphocytes, Cytotoxic-
dc.subject.keywordPlusTransfection-
dc.subject.keywordAuthorBreast cancer-
dc.subject.keywordAuthorImmunity-
dc.subject.keywordAuthorTrop-1-
dc.subject.keywordAuthorTumor antigen-
dc.subject.keywordAuthorVaccination-
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