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Interleukin-18 induces transferrin expression in breast cancer cell line MCF-7

Authors
Park, SunyoungYoon, Sun YoungKim, Kyung-EunLee, Ha ReumHur, Dae YoungSong, HyunkeunKim, DaejinBang, Sa IkCho, Dae-Ho
Issue Date
Dec-2009
Publisher
ELSEVIER IRELAND LTD
Keywords
Interleukin-18 (IL-18); Transferrin; Proliferation; Breast cancer
Citation
CANCER LETTERS, v.286, no.2, pp 189 - 195
Pages
7
Journal Title
CANCER LETTERS
Volume
286
Number
2
Start Page
189
End Page
195
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13625
DOI
10.1016/j.canlet.2009.05.025
ISSN
0304-3835
1872-7980
Abstract
Interleukin-18 (IL-18) has recently been shown to have a pro-cancer effect in various cancers. Increased serum levels of both IL-18 and transferrin in cancer patients are correlated with its malignancy. However, the relationship between transferrin and IL-18 is not well understood. Here, we show that exogenous transferrin enhanced breast cancer cell proliferation and the proliferation rate was reduced when endogenous transferrin expression was inhibited by transferrin siRNA. The expression of endogenous transferrin was found to be regulated by IL-18. Furthermore, we found that the MAPK pathway is involved in IL-18-induced transferrin production. In conclusion, IL-18 is suggested as an inducer of endogenous transferrin expression in breast cancer cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
원격대학원 > 향장미용학과 > 1. Journal Articles

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Kim, Kyung Eun
대학원 (헬스산업학(협동과정))
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