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Dietary Intake and Serum Levels of Iron in Relation to Oxidative Stress in Breast Cancer Patients

Authors
Bae, Yun-JungYeon, Jee-YoungSung, Chung-JaKim, Hyun-SookSung, Mi-Kyung
Issue Date
Nov-2009
Publisher
JOURNAL CLINICAL BIOCHEMISTRY & NUTRITION
Keywords
breast cancer; iron; oxidative stress; MDA
Citation
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, v.45, no.3, pp.355 - 360
Journal Title
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
Volume
45
Number
3
Start Page
355
End Page
360
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13656
DOI
10.3164/jcbn.09-46
ISSN
0912-0009
Abstract
Iron may induce oxidative stress via production of reactive oxygen species, facilitating mammary carcinogenesis. This study investigated the role of iron in relation to oxidative stress as a potential risk factor in the development of breast cancer (BC). BC patients (n = 121) and healthy age-matched controls (n = 149) were entered into the study. Iron and antioxidant vitamins intakes were estimated using a quantitative food frequency questionnaire. Thirty one subjects from each group provided blood samples for measurement of serum iron, plasma malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP). Total and non-heme iron intake of BC patients were lower than those of the controls. However, the serum iron level was significantly higher in BC patients. Plasma MDA levels were also significantly higher in BC patients whereas no significant difference in FRAP values were observed between the two groups. Log-transformed serum iron concentration showed no significant correlation with MDA or FRAP. These results suggest that serum iron overload may be a breast cancer risk factor possibly due to increased oxidative stress.
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생활과학대학 (식품영양학과)
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