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Enhanced S100A4 protein expression is clinicopathologically significant to metastatic potential and p53 dysfunction in colorectal cancer

Authors
Kim, Joo HeonKim, Chang NamKim, Soo YoungLee, Jung SamCho, DaehoKim, Jae WhaYoon, Sun Young
Issue Date
Jul-2009
Publisher
SPANDIDOS PUBL LTD
Keywords
S100A4; p53 transactivation; metastasis; colorectal carcinoma
Citation
ONCOLOGY REPORTS, v.22, no.1, pp.41 - 47
Journal Title
ONCOLOGY REPORTS
Volume
22
Number
1
Start Page
41
End Page
47
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13724
DOI
10.3892/or_00000404
ISSN
1021-335X
Abstract
To investigate the expression levels of S100A4 in human colorectal carcinoma (CC) and its relationship with clinicopathological parameters and metastatic potential, 73 pathological specimens from patients with CC were examined for S100A4 expression by RT-PCR and immunohistochemistry. An increase of S100A4 mRNA was observed in 19/23 (82.6%) CC specimens,and S100A4 was up-regulated in 40/73 (54.7%) CC cases compared with non-neoplastic mucosal tissues. Upregulation of S100A4 was significantly related to invasion, nodal status, distant metastasis and p53 expression. Next, we investigated whether S100A4 could affect p53 transactivation and stability. Interestingly, it was revealed that treatment with exogenous S100A4 protein reduced transcriptional activity of p53 and abrogated the modification of calcium binding, affinity of S100A4 protein. These findings suggested that S100A4 might be involved in the progression and metastasis of human CC, presumably via modulation of the wild-type p53 protein.
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles

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