Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages
DC Field | Value | Language |
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dc.contributor.author | Jin, Guo Hua | - |
dc.contributor.author | Lee, Da Yeon | - |
dc.contributor.author | Cheon, Ye-Jin | - |
dc.contributor.author | Gim, Hyo Jin | - |
dc.contributor.author | Kim, Do Hee | - |
dc.contributor.author | Kim, Hee-Doo | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.contributor.author | Jeon, Raok | - |
dc.date.available | 2021-02-22T14:17:01Z | - |
dc.date.issued | 2009-06-01 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.issn | 1464-3405 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13737 | - |
dc.description.abstract | A series of phenylisothioureas were synthesized as inhibitors of NO production in lipopolysaccharide-activated macrophages. We investigated the effect of lipophilic moiety and N- or S-substituents of the phenylisothioureas on the activity. Inhibitory activities of carbazole-linked phenylisothioureas were superior to the corresponding simple phenylisothiourea derivatives. Among these compounds, 12b having N- ethyl and S-isopropyl groups on phenylisothiourea moiety was the most potent in the inhibition of NO production. They inhibited NO production through the suppression of the LPS-induced translocation of p65 subunit of NF-kappa B and the followed suppression of the iNOS protein and mRNA expression. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PERGAMON-ELSEVIER SCIENCE LTD | - |
dc.title | Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.bmcl.2009.04.001 | - |
dc.identifier.scopusid | 2-s2.0-65149085044 | - |
dc.identifier.wosid | 000265981900043 | - |
dc.identifier.bibliographicCitation | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.11, pp 3088 - 3092 | - |
dc.citation.title | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - |
dc.citation.volume | 19 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 3088 | - |
dc.citation.endPage | 3092 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Organic | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | SELECTIVE-INHIBITION | - |
dc.subject.keywordPlus | ISOFORM SELECTIVITY | - |
dc.subject.keywordPlus | THERAPEUTIC TARGET | - |
dc.subject.keywordPlus | POTENT | - |
dc.subject.keywordPlus | PEROXYNITRITE | - |
dc.subject.keywordPlus | ISOTHIOUREAS | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordPlus | INOS | - |
dc.subject.keywordAuthor | Isothiourea | - |
dc.subject.keywordAuthor | Nitric oxide | - |
dc.subject.keywordAuthor | iNOS | - |
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