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Synthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages

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dc.contributor.authorJin, Guo Hua-
dc.contributor.authorLee, Da Yeon-
dc.contributor.authorCheon, Ye-Jin-
dc.contributor.authorGim, Hyo Jin-
dc.contributor.authorKim, Do Hee-
dc.contributor.authorKim, Hee-Doo-
dc.contributor.authorRyu, Jae-Ha-
dc.contributor.authorJeon, Raok-
dc.date.available2021-02-22T14:17:01Z-
dc.date.created2020-09-03-
dc.date.issued2009-06-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13737-
dc.description.abstractA series of phenylisothioureas were synthesized as inhibitors of NO production in lipopolysaccharide-activated macrophages. We investigated the effect of lipophilic moiety and N- or S-substituents of the phenylisothioureas on the activity. Inhibitory activities of carbazole-linked phenylisothioureas were superior to the corresponding simple phenylisothiourea derivatives. Among these compounds, 12b having N- ethyl and S-isopropyl groups on phenylisothiourea moiety was the most potent in the inhibition of NO production. They inhibited NO production through the suppression of the LPS-induced translocation of p65 subunit of NF-kappa B and the followed suppression of the iNOS protein and mRNA expression. (C) 2009 Elsevier Ltd. All rights reserved.-
dc.language영어-
dc.language.isoen-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectNITRIC-OXIDE SYNTHASE-
dc.subjectSELECTIVE-INHIBITION-
dc.subjectISOFORM SELECTIVITY-
dc.subjectTHERAPEUTIC TARGET-
dc.subjectPOTENT-
dc.subjectPEROXYNITRITE-
dc.subjectISOTHIOUREAS-
dc.subjectDESIGN-
dc.subjectENZYME-
dc.subjectINOS-
dc.titleSynthesis of phenylisothiourea derivatives as inhibitors of NO production in LPS activated macrophages-
dc.typeArticle-
dc.contributor.affiliatedAuthorKim, Hee-Doo-
dc.contributor.affiliatedAuthorRyu, Jae-Ha-
dc.contributor.affiliatedAuthorJeon, Raok-
dc.identifier.doi10.1016/j.bmcl.2009.04.001-
dc.identifier.scopusid2-s2.0-65149085044-
dc.identifier.wosid000265981900043-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.11, pp.3088 - 3092-
dc.relation.isPartOfBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume19-
dc.citation.number11-
dc.citation.startPage3088-
dc.citation.endPage3092-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusNITRIC-OXIDE SYNTHASE-
dc.subject.keywordPlusSELECTIVE-INHIBITION-
dc.subject.keywordPlusISOFORM SELECTIVITY-
dc.subject.keywordPlusTHERAPEUTIC TARGET-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusPEROXYNITRITE-
dc.subject.keywordPlusISOTHIOUREAS-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusENZYME-
dc.subject.keywordPlusINOS-
dc.subject.keywordAuthorIsothiourea-
dc.subject.keywordAuthorNitric oxide-
dc.subject.keywordAuthoriNOS-
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