Synthesis and characterization of poly(L-glutamic acid)-block-poly(L-phenylalanine)
- Authors
- Kim, Min Sang; Dayananda, Kasala; Choi, Eun Yung; Park, Heon Joo; Kim, Jin Seok; Lee, Doo Sung
- Issue Date
- 8-May-2009
- Publisher
- ELSEVIER SCI LTD
- Keywords
- Poly(L-glutamic acid); Poly(L-phenylalanine); pH dependent
- Citation
- POLYMER, v.50, no.10, pp 2252 - 2257
- Pages
- 6
- Journal Title
- POLYMER
- Volume
- 50
- Number
- 10
- Start Page
- 2252
- End Page
- 2257
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13756
- DOI
- 10.1016/j.polymer.2009.03.015
- ISSN
- 0032-3861
1873-2291
- Abstract
- Poly(gamma-benzyl-glutamate)-block-poly(L-Phenylalanine) was prepared via the ring opening polymerization of gamma-benzyl L-glutamate N-carboxyanhydride and L-phenylalanine N-carboxyanhydride using n-butylamine center dot HCl as an initiator for the living polymerization. Polymerization was confirmed by H-1-nuclear magnetic resonance spectroscopy and matrix assisted laser desorption ionization time of flight mass spectroscopy. After deprotection, the vesicular nanostructure of poly(L-glutamic acid)-block-poly (L-phenylalanine) particles was examined by transmission electron microscopy and dynamic light scattering. The pH-dependent properties of the nanoparticles were evaluated by means of zeta-potential and transmittance measurements. The results showed that the block copolypeptide could be prepared using simple techniques. Moreover, the easily prepared PGA-PPA block copolypeptide showed pH-dependent properties due to changes in the PGA ionization state as a function of pH; this characteristic could potentially be exploited for drug delivery applications. (C) 2009 Elsevier Ltd. All rights reserved.
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