Synthesis and characterization of poly(L-glutamic acid)-block-poly(L-phenylalanine)
DC Field | Value | Language |
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dc.contributor.author | Kim, Min Sang | - |
dc.contributor.author | Dayananda, Kasala | - |
dc.contributor.author | Choi, Eun Yung | - |
dc.contributor.author | Park, Heon Joo | - |
dc.contributor.author | Kim, Jin Seok | - |
dc.contributor.author | Lee, Doo Sung | - |
dc.date.available | 2021-02-22T14:17:15Z | - |
dc.date.issued | 2009-05-08 | - |
dc.identifier.issn | 0032-3861 | - |
dc.identifier.issn | 1873-2291 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13756 | - |
dc.description.abstract | Poly(gamma-benzyl-glutamate)-block-poly(L-Phenylalanine) was prepared via the ring opening polymerization of gamma-benzyl L-glutamate N-carboxyanhydride and L-phenylalanine N-carboxyanhydride using n-butylamine center dot HCl as an initiator for the living polymerization. Polymerization was confirmed by H-1-nuclear magnetic resonance spectroscopy and matrix assisted laser desorption ionization time of flight mass spectroscopy. After deprotection, the vesicular nanostructure of poly(L-glutamic acid)-block-poly (L-phenylalanine) particles was examined by transmission electron microscopy and dynamic light scattering. The pH-dependent properties of the nanoparticles were evaluated by means of zeta-potential and transmittance measurements. The results showed that the block copolypeptide could be prepared using simple techniques. Moreover, the easily prepared PGA-PPA block copolypeptide showed pH-dependent properties due to changes in the PGA ionization state as a function of pH; this characteristic could potentially be exploited for drug delivery applications. (C) 2009 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.title | Synthesis and characterization of poly(L-glutamic acid)-block-poly(L-phenylalanine) | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.polymer.2009.03.015 | - |
dc.identifier.scopusid | 2-s2.0-64549128250 | - |
dc.identifier.wosid | 000265954300008 | - |
dc.identifier.bibliographicCitation | POLYMER, v.50, no.10, pp 2252 - 2257 | - |
dc.citation.title | POLYMER | - |
dc.citation.volume | 50 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 2252 | - |
dc.citation.endPage | 2257 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.subject.keywordPlus | NANOSTRUCTURES | - |
dc.subject.keywordPlus | PACLITAXEL | - |
dc.subject.keywordPlus | VESICLES | - |
dc.subject.keywordPlus | ACID) | - |
dc.subject.keywordAuthor | Poly(L-glutamic acid) | - |
dc.subject.keywordAuthor | Poly(L-phenylalanine) | - |
dc.subject.keywordAuthor | pH dependent | - |
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