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ADAM33 regulates IL-18-secreted process in gastric cancer cells

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dc.contributor.authorKim, Kyung-Eun-
dc.contributor.authorCho, Dae-Ho-
dc.date.available2021-02-22T14:17:33Z-
dc.date.issued2009-04-
dc.identifier.issn0022-1767-
dc.identifier.issn1550-6606-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13778-
dc.description.abstractInterleukin (IL)-18 has recently been reported to play a critical role in tumor migration, invasion, and metastasis. Because IL-18 has various biological activities after its secretion as an 18 kDa mature form, the regulation of IL-18-secretion process is an important step in tumor progression. This study investigated the implication of IL-18 in vascular endothelial growth factor (VEGF)-D-regulated migration, along with the role of IL-18-secretion process. VEGF-D enhanced cell migration, which was then blocked by inhibiting IL-18. VEGF-D increased IL-18 expression and secretion, suggesting that IL-18 is a critical mediator for VEGF-D-enhanced migration. VEGF-D induced a disintegrin and metalloprotease 33 (ADAM33) expression, which has a metalloproteinase domain. VEGF-D-enhanced IL-18 secretion and cell migration were inhibited by ADAM33 knock-down. Moreover, cell proliferation was considerably reduced in ADAM33 siRNA transfectants. In conclusion, ADAM33 has a key role in gastric cancer pathogenesis by up-regulating IL-18 secretion process, resulting in increased cell migration and proliferation.-
dc.language영어-
dc.language.isoENG-
dc.publisherAMER ASSOC IMMUNOLOGISTS-
dc.titleADAM33 regulates IL-18-secreted process in gastric cancer cells-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.wosid000209763601291-
dc.identifier.bibliographicCitationJOURNAL OF IMMUNOLOGY, v.182, no.1-
dc.citation.titleJOURNAL OF IMMUNOLOGY-
dc.citation.volume182-
dc.citation.number1-
dc.type.docTypeMeeting Abstract-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.identifier.urlhttps://www.jimmunol.org/content/182/1_Supplement/88.4-
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
원격대학원 > 향장미용학과 > 1. Journal Articles

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