ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway
DC Field | Value | Language |
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dc.contributor.author | Jeon, Young Joo | - |
dc.contributor.author | Choi, Joon Seok | - |
dc.contributor.author | Lee, Jung Yun | - |
dc.contributor.author | Yu, Kyung Ryun | - |
dc.contributor.author | Kim, Sangman Michael | - |
dc.contributor.author | Ka, Seung Hyeun | - |
dc.contributor.author | Oh, Kyu Hee | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Zhang, Dong-Er | - |
dc.contributor.author | Bang, Ok Sun | - |
dc.contributor.author | Chung, Chin Ha | - |
dc.date.available | 2021-02-22T14:17:41Z | - |
dc.date.issued | 2009-04 | - |
dc.identifier.issn | 1469-221X | - |
dc.identifier.issn | 1469-3178 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13790 | - |
dc.description.abstract | Interferon (IFN)-induced signalling pathways have essential functions in innate immune responses. In response to type I IFNs, filamin B tethers RAC1 and a Jun N-terminal kinase (JNK)-specific mitogen-activated protein kinase ( MAPK) module-MEKK1, MKK4 and JNK-and thereby promotes the activation of JNK and JNK-mediated apoptosis. Here, we show that type I IFNs induce the conjugation of filamin B by interferon-stimulated gene 15 (ISG15). ISGylation of filamin B led to the release of RAC1, MEKK1 and MKK4 from the scaffold protein and thus to the prevention of sequential activation of the JNK cascade. By contrast, blockade of filamin B ISGylation by substitution of Lys 2467 with arginine or by knockdown of ubiquitin-activating enzyme E1-like (UBEL1) prevented the release of the signalling molecules from filamin B, resulting in persistent promotion of JNK activation and JNK-mediated apoptosis. These results indicate that filamin B ISGylation acts as a negative feedback regulatory gate for the desensitization of type I IFN-induced JNK signalling. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | WILEY | - |
dc.title | ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1038/embor.2009.23 | - |
dc.identifier.scopusid | 2-s2.0-64049089383 | - |
dc.identifier.wosid | 000264747600021 | - |
dc.identifier.bibliographicCitation | EMBO REPORTS, v.10, no.4, pp 374 - 380 | - |
dc.citation.title | EMBO REPORTS | - |
dc.citation.volume | 10 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 374 | - |
dc.citation.endPage | 380 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | INNATE ANTIVIRAL RESPONSE | - |
dc.subject.keywordPlus | UBIQUITIN E2 | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CONJUGATION | - |
dc.subject.keywordPlus | LIGASE | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | ISGYLATION | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | ENZYME | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | filamin B scaffold | - |
dc.subject.keywordAuthor | ISG15 | - |
dc.subject.keywordAuthor | JNK signalling pathway | - |
dc.subject.keywordAuthor | type I interferon | - |
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