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Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages

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dc.contributor.authorPark, Mi-Young-
dc.contributor.authorKwon, Hoon-Jeong-
dc.contributor.authorSung, Mi-Kyung-
dc.date.available2021-02-22T14:17:43Z-
dc.date.created2020-09-03-
dc.date.issued2009-04-
dc.identifier.issn0916-8451-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13792-
dc.description.abstractThe aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5-40 mu M. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E-2 (PGE(2)) production were suppressed by 40 mu M aloe-emodin. Aloin also suppressed the production of NO at 5-40 mu M, although it did not suppress PGE(2) production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aleo-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe.-
dc.language영어-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS LTD-
dc.subjectKAPPA-B ACTIVATION-
dc.subjectNITRIC-OXIDE SYNTHASE-
dc.subjectRAW 264.7 MACROPHAGES-
dc.subjectINTESTINAL BACTERIA-
dc.subjectAPOPTOTIC PATHWAY-
dc.subjectGENE-EXPRESSION-
dc.subjectCANCER CELLS-
dc.subjectCOLON-CANCER-
dc.subjectIN-VITRO-
dc.subjectINHIBITION-
dc.titleEvaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages-
dc.typeArticle-
dc.contributor.affiliatedAuthorSung, Mi-Kyung-
dc.identifier.doi10.1271/bbb.80714-
dc.identifier.scopusid2-s2.0-67149097678-
dc.identifier.wosid000265739200007-
dc.identifier.bibliographicCitationBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.73, no.4, pp.828 - 832-
dc.relation.isPartOfBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY-
dc.citation.titleBIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY-
dc.citation.volume73-
dc.citation.number4-
dc.citation.startPage828-
dc.citation.endPage832-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiotechnology & Applied Microbiology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalResearchAreaFood Science & Technology-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryBiotechnology & Applied Microbiology-
dc.relation.journalWebOfScienceCategoryChemistry, Applied-
dc.relation.journalWebOfScienceCategoryFood Science & Technology-
dc.subject.keywordPlusKAPPA-B ACTIVATION-
dc.subject.keywordPlusNITRIC-OXIDE SYNTHASE-
dc.subject.keywordPlusRAW 264.7 MACROPHAGES-
dc.subject.keywordPlusINTESTINAL BACTERIA-
dc.subject.keywordPlusAPOPTOTIC PATHWAY-
dc.subject.keywordPlusGENE-EXPRESSION-
dc.subject.keywordPlusCANCER CELLS-
dc.subject.keywordPlusCOLON-CANCER-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusINHIBITION-
dc.subject.keywordAuthoraloin-
dc.subject.keywordAuthoraloe-emodin-
dc.subject.keywordAuthorpolyphenol-
dc.subject.keywordAuthoranti-inflammatory effect-
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