Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages
DC Field | Value | Language |
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dc.contributor.author | Park, Mi-Young | - |
dc.contributor.author | Kwon, Hoon-Jeong | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.date.available | 2021-02-22T14:17:43Z | - |
dc.date.issued | 2009-04 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13792 | - |
dc.description.abstract | The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5-40 mu M. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E-2 (PGE(2)) production were suppressed by 40 mu M aloe-emodin. Aloin also suppressed the production of NO at 5-40 mu M, although it did not suppress PGE(2) production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aleo-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1271/bbb.80714 | - |
dc.identifier.scopusid | 2-s2.0-67149097678 | - |
dc.identifier.wosid | 000265739200007 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.73, no.4, pp 828 - 832 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 73 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 828 | - |
dc.citation.endPage | 832 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | KAPPA-B ACTIVATION | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | RAW 264.7 MACROPHAGES | - |
dc.subject.keywordPlus | INTESTINAL BACTERIA | - |
dc.subject.keywordPlus | APOPTOTIC PATHWAY | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | COLON-CANCER | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordAuthor | aloin | - |
dc.subject.keywordAuthor | aloe-emodin | - |
dc.subject.keywordAuthor | polyphenol | - |
dc.subject.keywordAuthor | anti-inflammatory effect | - |
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