Evaluation of Aloin and Aloe-Emodin as Anti-Inflammatory Agents in Aloe by Using Murine Macrophages
- Authors
- Park, Mi-Young; Kwon, Hoon-Jeong; Sung, Mi-Kyung
- Issue Date
- Apr-2009
- Publisher
- TAYLOR & FRANCIS LTD
- Keywords
- aloin; aloe-emodin; polyphenol; anti-inflammatory effect
- Citation
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.73, no.4, pp 828 - 832
- Pages
- 5
- Journal Title
- BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Volume
- 73
- Number
- 4
- Start Page
- 828
- End Page
- 832
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13792
- DOI
- 10.1271/bbb.80714
- ISSN
- 0916-8451
1347-6947
- Abstract
- The aloe ingredients responsible for physiological effects and the concentrations required to exert their biological activities are not fully understood. This study compares the anti-inflammatory effects of aloin and aloe-emodin with other polyphenols. Our results demonstrated that aloe-emodin dose-dependently inhibited inducible nitric oxide synthase (iNOS) mRNA expression and nitric oxide (NO) production at 5-40 mu M. In addition, the levels of cyclooxygenase-2 (COX-2) mRNA and prostaglandin E-2 (PGE(2)) production were suppressed by 40 mu M aloe-emodin. Aloin also suppressed the production of NO at 5-40 mu M, although it did not suppress PGE(2) production. The present results indicate that aloin and aloe-emodin possibly suppress the inflammatory responses by blocking iNOS and COX-2 mRNA expression. The anti-inflammatory effect of aleo-emodin was comparable to that of kaempferol and quercetin, indicating aloe-emodin as a possible key constituent responsible for the anti-inflammatory activity of aloe.
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