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Identification of WDR7 as a Novel Downstream Target of the EphA8-Odin Signaling Complex

Authors
Park, EunjeongPark, Soochul
Issue Date
Mar-2009
Publisher
TAYLOR & FRANCIS LTD
Keywords
Odin; Anks family protein; EphA8; WDR7
Citation
ANIMAL CELLS AND SYSTEMS, v.13, no.1, pp.9 - 15
Journal Title
ANIMAL CELLS AND SYSTEMS
Volume
13
Number
1
Start Page
9
End Page
15
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13801
DOI
10.1080/19768354.2009.9647189
ISSN
1976-8354
Abstract
Eph receptors and their ephrin ligands have been implicated in a variety of cellular processes such as cellular morphogenesis and motility. Our previous studies demonstrated that Odin, one of the Anks family proteins, functions as a scaffolding protein of the EphA8 signaling pathway leading to modulation of cell migration or axonal outgrowth. Here we show that WDR7 is associated with Odin and that it is possibly implicated in the EphA8 signaling pathway. WD40 repeats present in the COOH-terminal region of WDR7 appear to be crucial for its association with Odin, whereas the binding motif of Odin is located in between ankyrin repeats and PTB domain. Co-immunoprecipitation experiments revealed that association of WDR7 with Odin is enhanced by ephrin ligand treatment, possibly through forming large protein complexes including both EphA8 and ephrin-A5. Consistently, immunofluorescence staining experiments suggested that WDR7 constitute a component of the large protein complexes containing Odin, EphA8 and ephrin-A5. Taken together, our results suggest the WDR7-Odin complexes might be involved in the signaling pathway downstream of the EphA8 receptor.
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이과대학 (생명시스템학부)
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