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Thymosin beta 4 enhances NK cell cytotoxicity mediated by ICAM-1
- Authors
- Lee, Ha-reum; Yoon, Sun Young; Kang, Ho-Bum; Park, Sunyoung; Kim, Kyung-Eun; Cho, Young Hoon; Kim, Seonghan; Kim, Chul-woo; Cho, Byung Joo; Lee, Wang Jae; Bang, Sa Ik; Park, Hyunjeong; Cho, Daeho
- Issue Date
- Mar-2009
- Publisher
- ELSEVIER
- Keywords
- Thymosin beta 4; NK cell cytotoxicity; ICAM-1
- Citation
- IMMUNOLOGY LETTERS, v.123, no.1, pp 72 - 76
- Pages
- 5
- Journal Title
- IMMUNOLOGY LETTERS
- Volume
- 123
- Number
- 1
- Start Page
- 72
- End Page
- 76
- ISSN
- 0165-2478
1879-0542
- Abstract
- Thymosin beta 4 (T beta 4), which is the major G-actin sequestering protein, has been shown to have ubiquitous distribution and multiple biological activities. However, T beta 4's functions in relation to natural killer (NK) cells are still unknown. In this study, we show that synthetic T beta 4 peptide increases NK cell cytotoxicity mediated by intercellular adhesion molecule-1 (ICAM-1) through the secretion of cytolytic granules to target cells. This suggests that T beta 4 is a key activator of NK cell cytotoxicity. (C) 2009 Elsevier B.V. All rights reserved.
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