Development of novel mucoadhesive pellets of metformin hydrochloride
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Piao, Jingshu | - |
dc.contributor.author | Lee, Ji-Eun | - |
dc.contributor.author | Weon, Kwon-Yeon | - |
dc.contributor.author | Kim, Dong-Wook | - |
dc.contributor.author | Lee, Jung Suk | - |
dc.contributor.author | Park, James D. S. | - |
dc.contributor.author | Nishiyama, Yuichi | - |
dc.contributor.author | Fukui, Ikuo | - |
dc.contributor.author | Kim, Jin-Seok | - |
dc.date.available | 2021-02-22T14:18:06Z | - |
dc.date.issued | 2009-03 | - |
dc.identifier.issn | 0253-6269 | - |
dc.identifier.issn | 1976-3786 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13817 | - |
dc.description.abstract | Mucoadhesive polymer-coated pellets containing metformin hydrochloride were prepared by the powder-layering technique using a centrifugal fluidizing (CF)-granulator. Four high-viscosity polymers were applied to make the pellets: 1) hydroxymethylcellulose (HPMC), 2) sodium alginate (Na-Alg), 3) HPMC/Carbopol, and 4) sodium carboxylmethylcellulose (Na-CMC). The physical crushing test, mucoadhesive test, zeta-potential test, in vitro release study and observation of gastroretention state of the dosage form were performed to investigate the pellets. The strong adhesive interaction between the Na-CMC-coated pellets and the mucin disc was obtained by mucoadhesive test. Na-Alg was most effective among the polymers used in changing the value of zeta potential of the mucin solution by the interaction between a polymer and a mucin particle. Results from drug dissolution study showed that over 95% of the drug from all the four pellets was released before 2 h, while Na-CMC- and Na-Alg-coated pellets showed a moderate sustained-release in SGF (simulated gastric fluid) and SIF (simulated intestine fluid), respectively. In conclusion, Na-CMC and Na-Alg seem to be promising candidates for mucoadhesive formulation and further studies to improve the sustained-release property are underway for achieving the ultimate goal of once-a-day formulation of metformin hydrochloride. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | PHARMACEUTICAL SOC KOREA | - |
dc.title | Development of novel mucoadhesive pellets of metformin hydrochloride | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.1007/s12272-009-1312-0 | - |
dc.identifier.scopusid | 2-s2.0-65449149831 | - |
dc.identifier.wosid | 000265440100014 | - |
dc.identifier.bibliographicCitation | ARCHIVES OF PHARMACAL RESEARCH, v.32, no.3, pp 391 - 397 | - |
dc.citation.title | ARCHIVES OF PHARMACAL RESEARCH | - |
dc.citation.volume | 32 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 391 | - |
dc.citation.endPage | 397 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART001336133 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | SODIUM ALGINATE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DIABETES-MELLITUS | - |
dc.subject.keywordPlus | MATRIX TABLETS | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | FORMULATION | - |
dc.subject.keywordPlus | MICROSPHERES | - |
dc.subject.keywordPlus | CELLULOSE | - |
dc.subject.keywordPlus | POLYSACCHARIDE | - |
dc.subject.keywordAuthor | Powder-layering | - |
dc.subject.keywordAuthor | CF-granulator | - |
dc.subject.keywordAuthor | Mucoadhesion | - |
dc.subject.keywordAuthor | Polymer | - |
dc.subject.keywordAuthor | Pellets | - |
dc.subject.keywordAuthor | Metformin hydrochloride | - |
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