p34(SEI-1) Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34(SEI-1) as a Novel Target for Anti-Breast Cancer Strategies
DC Field | Value | Language |
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dc.contributor.author | Hong, Seung-Woo | - |
dc.contributor.author | Kim, Chang-Jae | - |
dc.contributor.author | Park, Won-Sang | - |
dc.contributor.author | Shin, Jae-Sik | - |
dc.contributor.author | Lee, Soon-Duck | - |
dc.contributor.author | Ko, Seong-Gyu | - |
dc.contributor.author | Jung, Sam-Il | - |
dc.contributor.author | Park, In-Chul | - |
dc.contributor.author | An, Sung-Kwan | - |
dc.contributor.author | Lee, Won-Keun | - |
dc.contributor.author | Lee, Wang-Jae | - |
dc.contributor.author | Jin, Dong-Hoon | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.date.available | 2021-02-22T14:18:11Z | - |
dc.date.issued | 2009-02 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.issn | 1538-7445 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13824 | - |
dc.description.abstract | The p34(SEI-1) protein exerts oncogenic effects via regulation of the cell cycle, which occurs through a direct interaction with cyclin-dependent kinase 4. Such regulation can increase the survival of various types of tumor cells. Here, we show that the antiapoptotic function of p34(SEI-1) increases tumor cell survival by protecting the X-linked inhibitor of apoptosis protein (XIAP) from degradation. Our findings show that p34(SEI-1) inhibits apoptosis. This antiapoptotic effect was eliminated by the suppression of p34(SEI-1) expression. We also determined that direct binding of p34(SEI-1) to the BIR2 domain prevents ubiquitination of XIAP. Interestingly, p34(SEI-1) expression is absent or weak in normal tissues but is strongly expressed in tissues obtained from patients with breast cancer. Furthermore, the expression levels of p34(SEI-1) and XIAP seem to be coordinated in human breast cancer cell lines and tumor tissues. Thus, our findings reveal that p34(SEI-1) uses a novel apoptosis-inhibiting mechanism to stabilize XIAP. [Cancer Res 2009;69(3):741-6] | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | AMER ASSOC CANCER RESEARCH | - |
dc.title | p34(SEI-1) Inhibits Apoptosis through the Stabilization of the X-Linked Inhibitor of Apoptosis Protein: p34(SEI-1) as a Novel Target for Anti-Breast Cancer Strategies | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1158/0008-5472.CAN-08-1189 | - |
dc.identifier.scopusid | 2-s2.0-59149083885 | - |
dc.identifier.wosid | 000263048700005 | - |
dc.identifier.bibliographicCitation | CANCER RESEARCH, v.69, no.3, pp 741 - 746 | - |
dc.citation.title | CANCER RESEARCH | - |
dc.citation.volume | 69 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 741 | - |
dc.citation.endPage | 746 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | XIAP | - |
dc.subject.keywordPlus | CARCINOMAS | - |
dc.subject.keywordPlus | SEI-1 | - |
dc.subject.keywordPlus | SMAC | - |
dc.identifier.url | https://cancerres.aacrjournals.org/content/69/3/741 | - |
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