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In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii
- Authors
- Kim, Jae Yeon; Lim, Hyo Jin; Lee, Da Yeon; Kim, Ji Sun; Kim, Do Hee; Lee, Hwa Jin; Kim, Hee Doo; Jeon, Raok; Ryu, Jae-Ha
- Issue Date
- 1-Feb-2009
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Magnolia fargesii; Nitric oxide; Prostaglandin E-2; Microglia
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.19, no.3, pp 937 - 940
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 19
- Number
- 3
- Start Page
- 937
- End Page
- 940
- ISSN
- 0960-894X
1464-3405
- Abstract
- The overproduction of nitric oxide (NO) and prostaglandin E-2 (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappa B-alpha degradation and nuclear translocation of p65 subunit of NF-kappa B. (C) 2009 Published by Elsevier Ltd.
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