Detailed Information

Cited 0 time in webofscience Cited 65 time in scopus
Metadata Downloads

Effects of Antioxidant Supplements Intervention on the Level of Plasma Inflammatory Molecules and Disease Severity of Rheumatoid Arthritis Patients

Authors
Bae, Sang-CheolJung, Won-JinLee, Eun-JuYu, RinaSung, Mi-Kyung
Issue Date
Feb-2009
Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
Keywords
rheumatoid arthritis; antioxidants; quercetin; alpha-lipoic acid; inflammation; TNF-alpha; IL-1 beta; IL-6; C-reactive protein
Citation
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION, v.28, no.1, pp.56 - 62
Journal Title
JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION
Volume
28
Number
1
Start Page
56
End Page
62
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13834
DOI
10.1080/07315724.2009.10719762
ISSN
0731-5724
Abstract
Objective: Excess generation of reactive oxygen species in damaged joints accelerates inflammatory responses in RA (rheumatoid arthritis) patients. The complementary effects of dietary antioxidant supplementation on the blood level of inflammatory mediators and the severity of the disease in RA patients were evaluated. Study Design and Settings: The study was conducted as a randomized, placebo-controlled, double-blind, three-treatment cross-over design trial. The participants visited the hospital as outpatients. Subjects: Twenty patients meeting the 1987 criteria for the classification of rheumatoid arthritis completed the study. Interventions: The subjects were randomized in three groups to receive one of following supplementation; quercetin + vitamin C (166mg + 133mg/capsule), alpha-lipoic acid (300mg/capsule) or placebo for 4 weeks (3 capsules/day). Each treatment period consisted of 4 weeks with 2 weeks of wash-out period before the subject starts next supplementation. Outcome Parameters: Serum levels of tumor necrosis factor-alpha(TNF-alpha), interleukin- 1 beta(IL-1 beta), interleukin -6(IL-6), and C-reactive protein (CRP) were measured. The severity of disease was evaluated using Korean Health Assessment Questionnaire(KHAQ) and Visual Analogue Scale(VAS). Nutrient intake was measured at baseline and at the end of each intervention period. Results: The mean energy and nutrient intakes remained constant during study period. No significant differences were found in the serum concentrations of pro-inflammatory cytokines and CRP between treatments. The scores of disease severity measurements were not significantly different between treatments, although quercetin supplementation had a tendency to reduce VAS. Conclusions: Dietary supplementation of antioxidants at 900 mg/day for 4 weeks did not change the blood biomarkers of inflammation and disease severity of RA patients under conventional medical treatments. Further considerations for dose-response relationships, duration of supplementation, and susceptible biomarkers are required.
Files in This Item
There are no files associated with this item.
Appears in
Collections
생활과학대학 > 식품영양학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Sung, Mi Kyung photo

Sung, Mi Kyung
생활과학대학 (식품영양학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE