Detailed Information

Cited 0 time in webofscience Cited 36 time in scopus
Metadata Downloads

SUMOylation of ROR alpha potentiates transcriptional activation function

Authors
Hwang, Eun JuLee, Ji MinJeong, JiyeongPark, Joo HyeonYang, YoungLim, Jong-SeokKim, Jung HwaBaek, Sung HeeKim, Keun Il
Issue Date
Jan-2009
Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
Keywords
ROR alpha; SUMO; SUMOylation; deSUMOylation; Ubc9; PIAS; SENP2
Citation
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.378, no.3, pp.513 - 517
Journal Title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume
378
Number
3
Start Page
513
End Page
517
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13838
DOI
10.1016/j.bbrc.2008.11.072
ISSN
0006-291X
Abstract
SUMOylation regulates a variety of cellular processes, including control of transcriptional activities of nuclear receptors. Here, we present SUMOylation of orphan nuclear receptor, ROR alpha by both SUMO-1 and SUMO-2. SUMOylation of ROR alpha occurred on the 240th lysine residue at the hinge region of human protein. PIAS family members, PIASx alpha, PIAS3, and PIASy, increased SUMOylation of ROR alpha, whereas SENP2 specifically removed SUMO from ROR alpha SUMOylation-defective mutant form of ROR alpha exhibited decreased transcriptional activity on ROR alpha-responsive promoters indicating that SUMOylation may positively regulate transcriptional function of ROR alpha. (C) 2008 Elsevier Inc. All rights reserved.
Files in This Item
Go to Link
Appears in
Collections
이과대학 > 생명시스템학부 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Yang, Young photo

Yang, Young
이과대학 (생명시스템학부)
Read more

Altmetrics

Total Views & Downloads

BROWSE