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B16F10에서 Tyrosinase 관련 효소에 대한 타우린 효과Effects of Taurine on Enzyme Related Tyrosinase in B16F10

Other Titles
Effects of Taurine on Enzyme Related Tyrosinase in B16F10
Authors
정효숙김안근
Issue Date
Dec-2009
Publisher
한국미용학회
Keywords
Taurine; Tyrosinase. TRP₁; TRP₂; Taurine; Tyrosinase. TRP₁; TRP₂
Citation
한국미용학회지, v.15, no.4, pp 1463 - 1469
Pages
7
Journal Title
한국미용학회지
Volume
15
Number
4
Start Page
1463
End Page
1469
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/13897
ISSN
1229-4349
Abstract
The level of UV radiation emitted by the sun is increasing due to the destruction of the ozone layer. Our skin is more exposed to UV radiation and often suffers from various harmful effects of UV. Melanin production in human skin is an important defense mechanism against UV and a major determinant of skin color. Despite the protective role of melanins, abnormal hyperpigmentation such as freckles, chloasma, and other forms of melanin hyperpigmentation sometimes can be serious aesthetic problems. Because of this effect of melanin, people have concerned the effect of whitening in cosmetics. Taurine has been shown to be tissue-protective in many models of oxidant-induced injury, and it is a powerful regulator of the immune system, anti-oxidant effect. I investigated the whitening effect of Taurine. The Cytotoxicity was measured by MTT assay. I measured the level of tyrosinase activity and inhibition of the melanin synthesis in B16F10 murine melanoma cell. To evaluate effects of taurine on enzyme related tyrosinase I examined tyrosinase activity, TRP₁,TRP₂by western blot and RT-PCR. Through such experiments, I gained the results that Taurine is able to be potential skin whitening agents in cosmetics.
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