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마우스 악성흑색종세포에서 L-Arginine이 항산화작용과 멜라닌생성에 미치는 영향The Effect of L-Arginine on Antioxidant Activity and Melanogenesis in Murine Melanoma Cells
- Other Titles
- The Effect of L-Arginine on Antioxidant Activity and Melanogenesis in Murine Melanoma Cells
- Issue Date
- Sep-2009
- Publisher
- 대한암예방학회
- Keywords
- L-Arginine; Antioxidant activity; Melanogenesis; Murine melanoma cells; ROS
- Citation
- 대한암예방학회지, v.14, no.3, pp 242 - 247
- Pages
- 6
- Journal Title
- 대한암예방학회지
- Volume
- 14
- Number
- 3
- Start Page
- 242
- End Page
- 247
- ISSN
- 2288-3649
2288-3657
- Abstract
- Pigmentation protects cells from harmful effects of sunlight or oxidative stress. It is due to the synthesis and dispersion of melanin. Our study has shown to melanogenesis effect of L-arginine on B16F10 cells, murine melanoma cells. L-arginine (0∼200 mM) exhibited effective cell growth inhibition dosedependently. L-arginine decrease level of ROS (reactive oxygen species). Further investigation revealed that L-arginine is a factor of melanogenesis. tyrosinase activity and Melanin contents increased dose dependent manner. Taken together, these findings suggest that L-arginine has to decrease the level of ROS, and increase tyrosinase activity and melanogenesis. (Cancer Prev Res 14, 242-247, 2009)
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