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Gene transfer of AIMP1 and B7.1 into epitope-loaded, fibroblasts induces tumor-specific CTL immunity, and prolongs the survival period of tumor-bearing mice

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dc.contributor.authorKim, Tae S.-
dc.contributor.authorLee, Byeong C.-
dc.contributor.authorKim, Eugene-
dc.contributor.authorCho, Daeho-
dc.contributor.authorCohen, Edward P.-
dc.date.available2021-02-22T14:32:36Z-
dc.date.issued2008-11-05-
dc.identifier.issn0264-410X-
dc.identifier.issn1358-8745-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14150-
dc.description.abstractT helper type I (Th1) cell-mediated immune responses play Various roles in cellular immunity, including inducing cytotoxic T lymphocytes (CTLs) and they have been shown to be crucial in cancer immunotherapy. Previously, we found that aminoacyl-tRNA synthetase-interacting multifunctional protein 1 (AIMP1) stimulated antigen-presenting cells to secrete IL-12, leading to enhanced Th I cell responses. In this Study, as a way of enhancing antigen-specific Th1 responses, mouse fibroblasts (H-2(b)) were genetically modified to express an AIMP I and a costimulatory B7.1 (Fb/AIMP1/B7.1). Fb/AIMP1/B7.1 cells were then loaded with an ovalbumin epitope as a model antigen (Fb/AIMP1/B7.1/OVA), and tested to determine if they induced OVA-specific cas in C57BL/6 mice (H-2(b)). Immunization with Fb/AIMP1/B7.1/OVA cells induced strong cytotoxic activities against OVA-expressing EG7 tumor cells, but not against other H-2(b) tumor cells. The levels of the cytotoxic response in the immunized mice with Fb/AIMP1/137.1/OVA cells were significantly higher than the responses in mice immunized with other cell constructs. CD8(+) T cells were a major cell-type of OVA-specific antitumor immunity induced by Fb/AIMP1/B7.1/OVA cells. Furthermore, treatment with Fb/AIMP1/B7.1/OVA cells significantly prolonged the survival period of EG7 tumor-bearing mice. These results indicate that AIMP1-secreting, epitope-loaded fibroblasts efficiently induce antigen-specific CTL responses in mice. (C) 2008 Elsevier Ltd. All rights reserved.-
dc.format.extent7-
dc.language영어-
dc.language.isoENG-
dc.publisherELSEVIER SCI LTD-
dc.titleGene transfer of AIMP1 and B7.1 into epitope-loaded, fibroblasts induces tumor-specific CTL immunity, and prolongs the survival period of tumor-bearing mice-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.vaccine.2008.08.051-
dc.identifier.scopusid2-s2.0-55049085234-
dc.identifier.wosid000261750200007-
dc.identifier.bibliographicCitationVACCINE, v.26, no.47, pp 5928 - 5934-
dc.citation.titleVACCINE-
dc.citation.volume26-
dc.citation.number47-
dc.citation.startPage5928-
dc.citation.endPage5934-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusANTITUMOR IMMUNITY-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusANTIGEN PRESENTATION-
dc.subject.keywordPlusCROSS-PRESENTATION-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusIMMUNOTHERAPY-
dc.subject.keywordPlusCOSTIMULATION-
dc.subject.keywordPlusCARCINOMA-
dc.subject.keywordAuthorFibroblast-
dc.subject.keywordAuthorAIMP1-
dc.subject.keywordAuthorB7.1-
dc.subject.keywordAuthorTumor immunity-
dc.subject.keywordAuthorVaccine-
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