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Effects of Hyperin, Isoquercitrin and Quercetin on Lipopolysaccharide-induced Nitrite Production in Rat Peritoneal Macrophages

Authors
Lee, SanghyunPark, Hee-SeungNotsu, YohkoBan, Hyun SeungKim, Yong PilIshihara, KenjiHirasawa, NoriyasuJung, Sang HoonLee, Yeon SilLim, Soon SungPark, Eun-HeeShin, Kuk HyunSeyama, ToshioHong, JangJaOhuchi, Kazuo
Issue Date
Nov-2008
Publisher
WILEY
Keywords
Acanthopanax chiisanensis; nitric oxide (NO); hyperin; isoquercitrin; quercetin; macrophages
Citation
PHYTOTHERAPY RESEARCH, v.22, no.11, pp 1552 - 1556
Pages
5
Journal Title
PHYTOTHERAPY RESEARCH
Volume
22
Number
11
Start Page
1552
End Page
1556
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14156
DOI
10.1002/ptr.2529
ISSN
0951-418X
1099-1573
Abstract
The extract of the root of Acanthopanax chiisanensis Nakai is used for the treatment of inflammation. To analyse the action mechanism of this extract, the effect of hyperin (quercetin-3-O-beta-D-galactose) isolated from the ethyl acetate fraction of the root of A. chiisanensis on nitrite production and induction of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS, 1 mu g/mL)-stimulated rat peritoneal macrophages were examined. The effect of the structurally related compounds, isoquercitrin (quercetin-3-O-beta-glucose) and quercetin (an aglycone of the two compounds) isolated from the extract of the leaves of Vaccinium koreanum Nakai was also examined to compare the effect. It was shown that hyperin inhibited the LPS-induced iNOS expression and nitrite production. Of the three compounds, quercetin showed the most potent inhibitory activity. The phosphorylation of p44/42 mitogen activated protein kinase (MAPK), p38 MAPK and c-Jun N-terminal kinase (JNK) were also inhibited by these compounds. These findings suggested that hyperin in the extract of the root of A. chiisanensis inhibits nitric oxide (NO) production through inhibition of the expression of iNOS by attenuation of p44/p42 MAPK, p38 MAPK and JNK, and thus participates in the antiinflammatory activity of the extract. Copyright (C) 2008 John Wiley & Sons, Ltd.
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