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IL-18 enhances ULBP2 expression through the MAPK pathway in leukemia cells

Authors
Song, HyunkeunKim, Kyung-EunHur, DaeyoungLim, Jong-SeokYang, YoungCho, Byung JooKim, Cherl-hyunKim, TaesungBang, SaicLee, Wang JaePark, HyunjeongCho, DaeHo
Issue Date
Sep-2008
Publisher
ELSEVIER SCIENCE BV
Keywords
IL-18; Natural killer cells; Tumor immunity; ULBP; NKG2D
Citation
IMMUNOLOGY LETTERS, v.120, no.1-2, pp 103 - 107
Pages
5
Journal Title
IMMUNOLOGY LETTERS
Volume
120
Number
1-2
Start Page
103
End Page
107
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14176
DOI
10.1016/j.imlet.2008.07.007
ISSN
0165-2478
1879-0542
Abstract
Expression of UL16-binding proteins (ULBPs) has been reported in various cancers, such as leukemia and melanoma, and also in some other cancer cell lines. However, the factors that modulate the expression of ULBPs are not well defined. In this study, we investigated the effects of IL-18 on the expression of NKG2D ligands in leukemia cells. IL-18 treatment increased ULBP2 expression in leukemia cells at the mRNA and protein levels. In addition, PD98059 (an ERK1/2 MAPK inhibitor) and SP600125 (a JNK inhibitor) attenuated IL-18-induced ULBP2 expression in a dose-dependent manner. We observed that ERK1/2 and JNK MAPK phosphorylation increased upon treatment with IL-18. IL-18 elevated CD107a expression in cancer cells and increased the cytotoxic activity of NK cells; therefore, we propose that IL-18 increases the susceptibility of target cells by inducing surface expression of ULBP2. Taken together, these findings suggest that IL-18 may play a critical role in regulating ULBP2 expression via the ERK1/2 and JNK MAPK pathways in leukemia cells. (C) 2008 Elsevier B.V. All rights reserved.
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대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
이과대학 > 생명시스템학부 > 1. Journal Articles
원격대학원 > 향장미용학과 > 1. Journal Articles

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