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Anti-inflammatory, Anti-Angiogenic and Anti-Nociceptive Activities of 4-Hydroxybenzaldehyde

Authors
Lim, Eun-JuKang, Hyun-JungJung, Hyun-JooKim, KyunghoonLim, Chang-JinPark, Eun-Hee
Issue Date
Sep-2008
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Keywords
Anti-angiogenic; Anti-inflammatory; Anti-nociceptive; Cyclooxygenase-2; 4-hydroxybenzaldehyde; Inducible nitric oxide synthase; Nitric oxide; RAW264.7; Reactive oxygen species
Citation
BIOMOLECULES & THERAPEUTICS, v.16, no.3, pp 231 - 236
Pages
6
Journal Title
BIOMOLECULES & THERAPEUTICS
Volume
16
Number
3
Start Page
231
End Page
236
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14197
DOI
10.4062/biomolther.2008.16.3.231
ISSN
1976-9148
2005-4483
Abstract
The current work was designed to assess novel pharmacological activities of 4-hydroxybenzaldehyde (HD), a major phenolic constituent of various natural products of plant origin, such as Gastrodia elata Blume. HID exhibited a significant inhibition in the chick chorioallantoic membrane (CAM) angiogenesis. HD also displayed an inhibitory effect in acetic acid-induced permeability in mice. Anti-nociceptive activity of HD was convinced using the acetic acid-induced writhing test in mice. HD was able to suppress production of nitric oxide (NO) and induction of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in the lipopolysaccharide (LPS)-activated RAW264.7 macrophages. HD also diminished the reactive oxygen species (ROS) level elevated in the LPS-activated macrophages. In brief, HD exhibits anti-angiogenic, anti-inflammatory and anti-nociceptive activities possibly via down-regulating iNOS and/or COX-2, which may be partly responsible for pharmacological efficacies of various natural products.
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