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Nuclear receptors and coregulators in inflammation and cancer
- Authors
- Lee, Jason S.; Kim, Keun Il; Baek, Sung Hee
- Issue Date
- Aug-2008
- Publisher
- ELSEVIER IRELAND LTD
- Keywords
- nuclear receptor; inflammation; cancer
- Citation
- CANCER LETTERS, v.267, no.2, pp 189 - 196
- Pages
- 8
- Journal Title
- CANCER LETTERS
- Volume
- 267
- Number
- 2
- Start Page
- 189
- End Page
- 196
- ISSN
- 0304-3835
1872-7980
- Abstract
- Functional role of nuclear receptors and numerous coregulators have been Studied in terms Of regulating transcriptional control of genes that play critical roles in various pathways. There is growing evidence that nuclear receptors and their coregulators control inflammatory programs of gene expression and progression of hormone-dependent cancer. This review provides a general overview of the interrelationship between nuclear receptor signalling, inflammation and cancer. These insights provide inflammatory genes as attractive targets for the development of cancer therapeutics. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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