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Synthesis of azaisoflavones and their inhibitory activities of NO production in activated microglia
- Authors
- Jin, Guo Hua; Ha, Sang Keun; Park, Hye Min; Kang, Bomi; Kim, Sun Yeou; Kim, Hee-Do; Ryu, Jae-Ha; Jeon, Raok
- Issue Date
- 15-Jul-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- azaisoflavone; nitric oxide; iNOS
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.14, pp 4092 - 4094
- Pages
- 3
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 18
- Number
- 14
- Start Page
- 4092
- End Page
- 4094
- ISSN
- 0960-894X
1464-3405
- Abstract
- A series of azaisoflavones were synthesized and their biological activities were evaluated for nitric oxide (NO) production and inducible NO synthase (iNOS) expression in BV-2 microglia cell lines. Among these compounds, compound 8d was the most potent with IC(50) 7.83 mu M for inhibition of NO production. Also, compound 8d inhibited expression of iNOS in LPS-induced BV2 cells. This result suggests that compound 8d inhibited the production of NO by suppressing the expression of iNOS. (c) 2008 Elsevier Ltd. All rights reserved.
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