PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells
DC Field | Value | Language |
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dc.contributor.author | Jang, Chan Ho | - |
dc.contributor.author | Lee, In Ae | - |
dc.contributor.author | Ha, Young Ran | - |
dc.contributor.author | Lim, Jinkyu | - |
dc.contributor.author | Sung, Mi-Kyung | - |
dc.contributor.author | Lee, Sung-Joon | - |
dc.contributor.author | Kim, Jong-Sang | - |
dc.date.available | 2021-02-22T14:33:32Z | - |
dc.date.issued | 2008-07 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14230 | - |
dc.description.abstract | Few protein biomarkers for oxidative stress have been reported. In this study, we attempted to identify the proteins selectively overexpressed in human colon tumor cells by treating with hydrogen peroxide as oxidative stress. A proteomic analysis followed by western blotting showed that phosphoglycerate kinase 1 (PGK1) was induced by hydrogen peroxide in a dose-dependent manner, while its expression was suppressed by a co-treatment with delphinidin, a known antioxidant. Furthermore, several antioxidants, including alpha-tocopherol, butylated hydroxytoluene (BHT), and Trolox, also inhibited the PGK1 induction caused by hydrogen peroxide. The data suggest that PGK1 might be a potential protein biomarker of intracellular oxidative status. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1271/bbb.80079 | - |
dc.identifier.scopusid | 2-s2.0-47949128698 | - |
dc.identifier.wosid | 000258124700020 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.72, no.7, pp 1799 - 1808 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 72 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 1799 | - |
dc.citation.endPage | 1808 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | HYPOXIA-INDUCIBLE FACTOR | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | PROTEINS | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | ANTHOCYANINS | - |
dc.subject.keywordPlus | DELPHINIDIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | phosphoglycerate kinase 1 (PGK1) | - |
dc.subject.keywordAuthor | oxidative stress | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | biomarker | - |
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