Resveratrol induces the suppression of tumor-driven CD4(+) CD25(+) regulatory T cells
- Authors
- Yang, Yoolhee; Paik, Jin Ho; Cho, Daeho; Cho, Jung-Ah; Kim, Chul-Woo
- Issue Date
- Apr-2008
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- resveratrol; regulatory T cell; FoxP3; TGF-beta
- Citation
- INTERNATIONAL IMMUNOPHARMACOLOGY, v.8, no.4, pp 542 - 547
- Pages
- 6
- Journal Title
- INTERNATIONAL IMMUNOPHARMACOLOGY
- Volume
- 8
- Number
- 4
- Start Page
- 542
- End Page
- 547
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14286
- DOI
- 10.1016/j.intimp.2007.12.006
- ISSN
- 1567-5769
1878-1705
- Abstract
- CD4(+)CD25(+) regulatory T cells (Treg cells) are negative regulator of the immune system and main obstacles to cancer immunotherapy in tumor-bearing hosts. Resveratrol is a natural product found in grapes with both immunomodulatory and anticancer effects, which can be controlled by Treg cells. Therefore, to determine whether resveratrol performs these actions via Treg cells, we investigated changes in Treg cell population and immunomodulatory cytokines in EG7 tumorbearing C57BL/6 mice. In the present study, CD4(+)CD25(+) cell population among CD4(+) cells was inhibited ex vivo by resveratrol treatment in a dose-dependent manner. FoxP3(+) expressing cells among CD4(+)CD25(+) population were significantly reduced after resveratrol. treatment ex vivo in intracellular FACS analysis. Single intraperitoneat administration of 4 mg/kg resveratrol suppressed the CD4(+)CD25(+) cell population among CD4(+) cells and downregulated secretion of TGF-beta, an immunosuppressive cytokine, measured from the spleens of tumor-bearing mice. Furthermore, resveratrol enhanced IFN-gamma expression in CD8(+) T cells both ex vivo and in vivo, leading to immune stimulation. Taken together, these results suggest that resveratrol. has a suppressive rote on CD4(+)CD25(+) cell population and makes periturnoral microenvironment unfavorable to tumor in tumor-bearing mice. Thus, resveratrot can be considered as possible adjuvant material for vaccination -based cancer therapy. (c) 2007 Elsevier B. V. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 대학 > 기초교양대학 > 기초교양학부 > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.