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In vitro anti-inflammatory activity of 3-O-methyl-flavones isolated from Siegesbeckia glabrescens
- Authors
- Kim, Jae Yeon; Lim, Hyo Jin; Ryu, Jae-Ha
- Issue Date
- 15-Feb-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Siegesbeckia glabrescens; nitric oxide synthase; peroxynitrite
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.4, pp 1511 - 1514
- Pages
- 4
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 18
- Number
- 4
- Start Page
- 1511
- End Page
- 1514
- ISSN
- 0960-894X
1464-3405
- Abstract
- Four flavones, 3,4'- O- dimethylquercetin (1), 3,7- O- dimethylquercetin (2), 3- O- methylquercetin (3) and 3,7,4'- O- trimethylquercetin (4) were isolated as the inhibitors of nitric oxide production in activated microglia (IC50 values: 11.1, 4.2, 3.8, and 25.1 mu M, respectively). They suppressed the expression of protein and mRNA of inducible nitric oxide synthase. Furthermore, compounds 2 and 3 showed scavenging activity of peroxynitrite with SC50 values of 1.75 and 0.77 mu M, respectively. (C) 2007 Elsevier Ltd. All rights reserved.
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