Coorperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues
DC Field | Value | Language |
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dc.contributor.author | Wookyung Yu | - |
dc.contributor.author | Kwanghoon Chung | - |
dc.contributor.author | Mookyung Cheon | - |
dc.contributor.author | Muyoung Heo | - |
dc.contributor.author | Kyou-hoon Han | - |
dc.contributor.author | Sihyun Ham | - |
dc.contributor.author | Iksoo Chang | - |
dc.date.available | 2021-02-22T14:47:02Z | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14344 | - |
dc.description.abstract | Recent experiments claiming that Naf-BBL protein follows a global downhill folding raised an important controversy as to the folding mechanism of fast-folding proteins. Under the global downhill folding scenario, not only do proteins undergo a gradual folding, but folding events along the continuous folding pathway also could be mapped out from the equilibrium denaturation experiment. Based on the exact calculation using a free energy landscape, relaxation eigenmodes from a master equation, and Monte Carlo simulation of an extended Muñoz–Eaton model that incorporates multiscale-heterogeneous pairwise interactions between amino acids, here we show that the very nature of a two-state cooperative transition such as a bimodal distribution from an exact free energy landscape and biphasic relaxation kinetics manifest in the thermodynamics and folding–unfolding kinetics of BBL and peripheral subunit-binding domain homologues. Our results provide an unequivocal resolution to the fundamental controversy related to the global downhill folding scheme, whose applicability to other proteins should be critically reexamined. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | Coorperative folding kinetics of BBL protein and peripheral subunit-binding domain homologues | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1073/pnas.0708480105 | - |
dc.identifier.scopusid | 2-s2.0-40649105020 | - |
dc.identifier.wosid | 000253469900029 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.105, no. 7, pp 2397 - 2402 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 105 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 2397 | - |
dc.citation.endPage | 2402 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.identifier.url | https://www.pnas.org/content/105/7/2397.short | - |
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