Garlic (Allium sativum) extract inhibits lipopolysaccharide-induced toll-like receptor 4 dimerization
DC Field | Value | Language |
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dc.contributor.author | Youn, Hyting-Sun | - |
dc.contributor.author | Lim, Hyo Jin | - |
dc.contributor.author | Lee, Hwa Jin | - |
dc.contributor.author | Hwang, Daniel | - |
dc.contributor.author | 양미희 | - |
dc.contributor.author | Jeon, Raok | - |
dc.contributor.author | Ryu, Jae-Ha | - |
dc.date.available | 2021-02-22T14:47:09Z | - |
dc.date.issued | 2008-02 | - |
dc.identifier.issn | 0916-8451 | - |
dc.identifier.issn | 1347-6947 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14355 | - |
dc.description.abstract | Garlic has long been used as a folk medicine. Numerous studies have demonstrated that a garlic extract and its sulfur-containing compounds inhibited nuclear factor kappa B (NF-kappa B) activation induced by various receptor agonists including lipopolysaccharide (LPS). Toll-like receptors (TLRs) play a key role in sensing diverse microbial products and inducing innate immune responses. The dimerization of TLR4 is required for the activation of downstream signaling pathways, including NF-kappa B. Therefore, TLR4 dimerization may be one of the first lines of regulation in activating LPS-induced signaling pathways. We report here biochemical evidence that the ethyl acetate fraction of garlic inhibited the LPS-induced dimerization of TLR4, resulting in the inhibition of NF-kappa B activation and the expression of cyclooxygenase 2 and inducible nitric oxide synthase. Our results demonstrate for the first time that a garlic extract can directly inhibit the TLRs-mediated signaling pathway at the receptor level. These results shed a new insight into understanding how garlic modulates the immune responses that could modify the risk of many chronic diseases. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.title | Garlic (Allium sativum) extract inhibits lipopolysaccharide-induced toll-like receptor 4 dimerization | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1271/bbb.70434 | - |
dc.identifier.scopusid | 2-s2.0-40449120671 | - |
dc.identifier.wosid | 000253892800013 | - |
dc.identifier.bibliographicCitation | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, v.72, no.2, pp 368 - 375 | - |
dc.citation.title | BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | - |
dc.citation.volume | 72 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 368 | - |
dc.citation.endPage | 375 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Applied | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | DIALLYL SULFIDE | - |
dc.subject.keywordPlus | CUTTING EDGE | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPONENT | - |
dc.subject.keywordPlus | TLR4 | - |
dc.subject.keywordPlus | TOLL-LIKE-RECEPTOR-4 | - |
dc.subject.keywordPlus | HOMODIMERIZATION | - |
dc.subject.keywordAuthor | garlic | - |
dc.subject.keywordAuthor | toll-like receptor | - |
dc.subject.keywordAuthor | cyclooxygenase | - |
dc.subject.keywordAuthor | nitric oxide synthase | - |
dc.identifier.url | https://doi.org/10.1271/bbb.70434 | - |
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