The Regulation of Taurine Transport through the Blood-Placental Barrier under Oxidative Stress
- Authors
- 강영숙; Yoo-Geum Yoon
- Issue Date
- Oct-2008
- Publisher
- 한국약제학회
- Keywords
- Blood-placental barrier; TR-TBT; Taurine transporter; Oxidative stress; Calcium ion
- Citation
- 약제학회지, v.38, no.5, pp 295 - 302
- Pages
- 8
- Journal Title
- 약제학회지
- Volume
- 38
- Number
- 5
- Start Page
- 295
- End Page
- 302
- URI
- https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14361
- ISSN
- 2093-5552
2093-6214
- Abstract
- In the present study, we examined the changes of uptake and efflux of taurine under various conditions
inducing oxidative stress using rat conditionally immortalized syncytiotrophoblast cell line, TR-TBT cell, as blood-placental
barrier in vitro model. In addition, we identified the characteristics of taurine transport in TR-TBT cells including general
features, besides effect of calcium ion on taurine transport. Taurine uptake showed time, Na+ and Cl− dependency, and was
decreased by PKC activator in TR-TBT cells. Also, calcium free condition decreased taurine uptake and evoked taurine
efflux in the cells. Oxidative stress induced the change of taurine transport in TR-TBT cells, but the changes were different
depending on the types of stimulation inducing oxidative stress. The taurine uptake was increased by TNF-α, LPS and DEM
stimulation but decreased by H2O2 and NO stimulation. Also, the taurine efflux was regulated by TNF-α stimulation. In conclusion,
the taurine transport through the blood-placental barrier was regulated in oxidative stress conditions, and these
results demonstrated that oxidative stress affected the taurine supplies to fetus and taurine level of fetus.
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