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The Regulation of Taurine Transport through the Blood-Placental Barrier under Oxidative Stress

Authors
강영숙Yoo-Geum Yoon
Issue Date
Oct-2008
Publisher
한국약제학회
Keywords
Blood-placental barrier; TR-TBT; Taurine transporter; Oxidative stress; Calcium ion
Citation
약제학회지, v.38, no.5, pp 295 - 302
Pages
8
Journal Title
약제학회지
Volume
38
Number
5
Start Page
295
End Page
302
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14361
ISSN
2093-5552
2093-6214
Abstract
In the present study, we examined the changes of uptake and efflux of taurine under various conditions inducing oxidative stress using rat conditionally immortalized syncytiotrophoblast cell line, TR-TBT cell, as blood-placental barrier in vitro model. In addition, we identified the characteristics of taurine transport in TR-TBT cells including general features, besides effect of calcium ion on taurine transport. Taurine uptake showed time, Na+ and Cl− dependency, and was decreased by PKC activator in TR-TBT cells. Also, calcium free condition decreased taurine uptake and evoked taurine efflux in the cells. Oxidative stress induced the change of taurine transport in TR-TBT cells, but the changes were different depending on the types of stimulation inducing oxidative stress. The taurine uptake was increased by TNF-α, LPS and DEM stimulation but decreased by H2O2 and NO stimulation. Also, the taurine efflux was regulated by TNF-α stimulation. In conclusion, the taurine transport through the blood-placental barrier was regulated in oxidative stress conditions, and these results demonstrated that oxidative stress affected the taurine supplies to fetus and taurine level of fetus.
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