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황촉규 추출물의 Nitric Oxide 생성 저해활성Inhibition of Nitric Oxide Production by the Extracts of Hibiscus manihot
- Other Titles
- Inhibition of Nitric Oxide Production by the Extracts of Hibiscus manihot
- Issue Date
- Aug-2008
- Publisher
- 대한약학회
- Keywords
- Hibiscus manihot; i-NOS; COX-2; RAW264.7 cells
- Citation
- 약 학 회 지, v.52, no.4, pp 259 - 263
- Pages
- 5
- Journal Title
- 약 학 회 지
- Volume
- 52
- Number
- 4
- Start Page
- 259
- End Page
- 263
- ISSN
- 0377-9556
- Abstract
- Anti-inflammatory activity of the extracts of Hibiscus manihot was investigated through the evaluation of its inhibitory effect on the production of inflammatory biomarkers (i-NOS, COX-2) in RAW264.7 murine macrophage cells. Among the sequential solvent fractions (hexane, dichloromethane, ethyl acetate, n-butanol and water), the fractions of dichloromethane (1 μg/ml) and ethyl acetate (5 μg/ml) showed potential inhibitory activities on i-NOS and COX-2 activity in RAW264.7 cells. These results suggest that Hibiscus manihot might have an anti-inflammatory activity through the suppression of inflammatory markers.
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