SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Jung Hwa | - |
dc.contributor.author | Lee, A. Min | - |
dc.contributor.author | Nam, Hye Jin | - |
dc.contributor.author | Choi, Hee June | - |
dc.contributor.author | Yang, Jung Woo | - |
dc.contributor.author | Lee, Jason S. | - |
dc.contributor.author | Kim, Mi Hyang | - |
dc.contributor.author | Kim, Su-Il | - |
dc.contributor.author | Chung, Chin Ha | - |
dc.contributor.author | Kim, Keun Il | - |
dc.contributor.author | Baek, Sung Hee | - |
dc.date.available | 2021-02-22T15:01:27Z | - |
dc.date.issued | 2007-12 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.issn | 1091-6490 | - |
dc.identifier.uri | https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14591 | - |
dc.description.abstract | Posttranslational modification by small ubiquitin-like modifier (SUMO) controls diverse cellular functions of transcription factors and coregulators and participates in various cellular processes including signal transduction and transcriptional regulation. Here, we report that pontin, a component of chromatin-remodeling complexes, is SUMO-modified, and that SUMOylation of pontin is an active control mechanism for the transcriptional regulation of pontin on androgen-receptor target genes in prostate cancer cells. Biochemical purification of pontin-containing complexes revealed the presence of the Ubc9 SUIVIO-conjugating enzyme that underlies its function as an activator. Intriguingly, 5 alpha-dihydroxytestosterone treatments significantly increased the SUMOylation of pontin, and SUMOylated pontin showed further activation of a subset of nuclear receptor-dependent transcription and led to an increase in proliferation and growth of prostate cancer cells. These data clearly define a functional model and provide a link between SUMO modification and prostate cancer progression. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.title | SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1073/pnas.0710343105 | - |
dc.identifier.scopusid | 2-s2.0-38049181050 | - |
dc.identifier.wosid | 000252077400033 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.104, no.52, pp 20793 - 20798 | - |
dc.citation.title | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.citation.volume | 104 | - |
dc.citation.number | 52 | - |
dc.citation.startPage | 20793 | - |
dc.citation.endPage | 20798 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ANDROGEN-RECEPTOR | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | SUMO | - |
dc.subject.keywordPlus | UBIQUITIN | - |
dc.subject.keywordPlus | REPRESSION | - |
dc.subject.keywordPlus | PREVENTS | - |
dc.subject.keywordPlus | REPTIN | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | CHAINS | - |
dc.subject.keywordAuthor | androgen receptor | - |
dc.subject.keywordAuthor | SUMO | - |
dc.subject.keywordAuthor | Ubc9 | - |
dc.subject.keywordAuthor | transcription | - |
dc.subject.keywordAuthor | proliferation | - |
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