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Broussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin beta 1 expression

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dc.contributor.authorKim, Jae Hyeon-
dc.contributor.authorKim, Sunho-
dc.contributor.authorHan, Surim-
dc.contributor.authorAhn, Eun-Kyung-
dc.contributor.authorCho, Young-Rak-
dc.contributor.authorJeong, Wonsik-
dc.contributor.authorKim, Sung Joon-
dc.contributor.authorBae, Gyu-Un-
dc.contributor.authorOh, Joa Sub-
dc.contributor.authorSeo, Dong-Wan-
dc.date.accessioned2022-04-19T08:43:32Z-
dc.date.available2022-04-19T08:43:32Z-
dc.date.issued2022-02-
dc.identifier.issn1582-1838-
dc.identifier.issn1582-4934-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/145929-
dc.description.abstractIn the present study, we demonstrate the regulatory effects and mechanism of broussonin A and B, diphenylpropane derivatives isolated from Broussonetia kazinoki, on vascular endothelial growth factor-A (VEGF-A)-stimulated endothelial cell responses in vitro and microvessel sprouting ex vivo. Treatment with broussonin A or B suppressed VEGF-A-stimulated endothelial cell proliferation by regulating the expression of cell cycle-related proteins and the phosphorylation status of retinoblastoma protein. In addition, treatment with broussonin A or B abrogated VEGF-A-stimulated angiogenic responses including endothelial cell migration, invasion, tube formation and microvessel formation from rat aortic rings. These anti-angiogenic activities of broussonin A and B were mediated through inactivation of VEGF-A-stimulated downstream signalling pathways, localization of vascular endothelial-cadherin at cell-cell contacts, and down-regulation of integrin beta 1 and integrin-liked kinase. Furthermore, treatment with broussonin A or B inhibited proliferation and invasion of non-small cell lung cancer and ovarian cancer cells. Taken together, our findings suggest the pharmacological potential of broussonin A and B in the regulation of angiogenesis, cancer cell growth and progression.-
dc.format.extent12-
dc.language영어-
dc.language.isoENG-
dc.publisherWILEY-
dc.titleBroussonin A- and B-mediated inhibition of angiogenesis by blockade of VEGFR-2 signalling pathways and integrin beta 1 expression-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/jcmm.17173-
dc.identifier.scopusid2-s2.0-85122324663-
dc.identifier.wosid000739732900001-
dc.identifier.bibliographicCitationJOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.26, no.4, pp 1194 - 1205-
dc.citation.titleJOURNAL OF CELLULAR AND MOLECULAR MEDICINE-
dc.citation.volume26-
dc.citation.number4-
dc.citation.startPage1194-
dc.citation.endPage1205-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaCell Biology-
dc.relation.journalResearchAreaResearch & Experimental Medicine-
dc.relation.journalWebOfScienceCategoryCell Biology-
dc.relation.journalWebOfScienceCategoryMedicine, Research & Experimental-
dc.subject.keywordPlusENDOTHELIAL-CELL PROLIFERATION-
dc.subject.keywordPlusANEMARRHENA-ASPHODELOIDES-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusTYROSINE PHOSPHORYLATION-
dc.subject.keywordPlusSIEGESBECKIA-GLABRESCENS-
dc.subject.keywordPlusADHERENS JUNCTIONS-
dc.subject.keywordPlusOVARIAN-CANCER-
dc.subject.keywordPlusKAZINOL-B-
dc.subject.keywordPlusMIGRATION-
dc.subject.keywordPlusSUPPRESSION-
dc.subject.keywordAuthorbroussonin A-
dc.subject.keywordAuthorbroussonin B-
dc.subject.keywordAuthorintegrin beta 1-
dc.subject.keywordAuthorvascular endothelial growth factor-
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/10.1111/jcmm.17173-
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