Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLC gamma 1 Signal Transduction Pathway

Authors
Kim, Myun SooPark, DongminLee, SoraPark, SunyoungKim, Kyung EunKim, Tae SungPark, Hyun JeongCho, Daeho
Issue Date
Jan-2022
Publisher
MDPI
Keywords
Erdr1; TCR signal modulation; PLC gamma 1
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.2
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
23
Number
2
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/145950
DOI
10.3390/ijms23020844
ISSN
1661-6596
Abstract
Erythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLC gamma 1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLC gamma 1/Ca2+/NFAT1 signal transduction pathway.
Files in This Item
There are no files associated with this item.
Appears in
Collections
원격대학원 > 향장미용학과 > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Kim, Kyung Eun photo

Kim, Kyung Eun
원격대학원 (향장미용학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE