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Erythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLC gamma 1 Signal Transduction Pathway

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dc.contributor.authorKim, Myun Soo-
dc.contributor.authorPark, Dongmin-
dc.contributor.authorLee, Sora-
dc.contributor.authorPark, Sunyoung-
dc.contributor.authorKim, Kyung Eun-
dc.contributor.authorKim, Tae Sung-
dc.contributor.authorPark, Hyun Jeong-
dc.contributor.authorCho, Daeho-
dc.date.accessioned2022-04-19T08:44:17Z-
dc.date.available2022-04-19T08:44:17Z-
dc.date.issued2022-01-
dc.identifier.issn1661-6596-
dc.identifier.issn1422-0067-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/145950-
dc.description.abstractErythroid differentiation regulator 1 (Erdr1) has previously been reported to control thymocyte selection via TCR signal regulation, but the effect of Erdr1 as a TCR signaling modulator was not studied in peripheral T cells. In this report, it was determined whether Erdr1 affected TCR signaling strength in CD4 T cells. Results revealed that Erdr1 significantly enhanced the anti-TCR antibody-mediated activation and proliferation of T cells while failing to activate T cells in the absence of TCR stimulation. In addition, Erdr1 amplified Ca2+ influx and the phosphorylation of PLC gamma 1 in CD4 T cells with the TCR stimuli. Furthermore, NFAT1 translocation into nuclei in CD4 T cells was also significantly promoted by Erdr1 in the presence of TCR stimulation. Taken together, our results indicate that Erdr1 positively modulates TCR signaling strength via enhancing the PLC gamma 1/Ca2+/NFAT1 signal transduction pathway.-
dc.language영어-
dc.language.isoENG-
dc.publisherMDPI-
dc.titleErythroid Differentiation Regulator 1 Strengthens TCR Signaling by Enhancing PLC gamma 1 Signal Transduction Pathway-
dc.typeArticle-
dc.publisher.location스위스-
dc.identifier.doi10.3390/ijms23020844-
dc.identifier.scopusid2-s2.0-85122778300-
dc.identifier.wosid000747863000001-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.2-
dc.citation.titleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.citation.volume23-
dc.citation.number2-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.subject.keywordPlusT-CELL-ACTIVATION-
dc.subject.keywordPlusNFAT-
dc.subject.keywordPlusTRANSCRIPTION-
dc.subject.keywordPlusPLAYS-
dc.subject.keywordPlusGENE-
dc.subject.keywordAuthorErdr1-
dc.subject.keywordAuthorTCR signal modulation-
dc.subject.keywordAuthorPLC gamma 1-
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