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hnRNP Q and hnRNP A1 Regulate the Translation of Cofilin in Response to Transient Oxygen-Glucose Deprivation in Hippocampal Neurons

Authors
Kim, Sung WookHong, In KyungKim, MingeeSong, Yun SeonKim, Kyong-Tai
Issue Date
Dec-2021
Publisher
MDPI
Keywords
oxygen-glucose deprivation; cofilin-actin aggregates; mRNA translation; neurodegeneration; RNA-binding proteins
Citation
CELLS, v.10, no.12
Journal Title
CELLS
Volume
10
Number
12
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/145991
DOI
10.3390/cells10123567
ISSN
2073-4409
2073-4409
Abstract
Protein aggregates of cofilin and actin have been found in neurons under oxygen-glucose deprivation. However, the regulatory mechanism behind the expression of Cfl1 during oxygen-glucose deprivation remains unclear. Here, we found that heterogeneous nuclear ribonucleoproteins (hnRNP) Q and hnRNP A1 regulate the translation of Cfl1 mRNA, and formation of cofilin-actin aggregates. The interaction between hnRNP A1 and Cfl1 mRNA was interrupted by hnRNP Q under normal conditions, while the changes in the expression and localization of hnRNP Q and hnRNP A1 increased such interaction, as did the translation of Cfl1 mRNA under oxygen-glucose deprived conditions. These findings reveal a new translational regulatory mechanism of Cfl1 mRNA in hippocampal neurons under oxygen-glucose deprivation.
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