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Anti-obesity effects of Lactobacillus rhamnosus 4B15, and its synergy with hydrolysed lactose skim milk powder

Authors
Kim, SejeongJoung, Jae YeonKang, Dae-KyungOh, Nam SuYoon, Yohan
Issue Date
Dec-2021
Publisher
ELSEVIER SCI LTD
Citation
INTERNATIONAL DAIRY JOURNAL, v.123
Journal Title
INTERNATIONAL DAIRY JOURNAL
Volume
123
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/146080
DOI
10.1016/j.idairyj.2021.104997
ISSN
0958-6946
1879-0143
Abstract
In the present study, the anti-obesity effects of probiotic (Lactobacillus rhamnosus 4B15), prebiotic (hydrolysed lactose skim milk powder), and synbiotic (L. rhamnosus 4B15 + hydrolysed lactose skim milk powder) were evaluated. Five-week-old C57BL/6N mice were fed a 45% fat diet (HFD, high-fat diet) to induce obesity. Mice administered phosphate-buffered saline (PBS) served as the control group. The treatments were simultaneously administered for 10 weeks. Consequently, the synbiotic reduced body fat accumulation and liver damage in obese mice, to a greater degree than the corresponding parameters in probiotic-and prebiotic-treated mice. Synbiotic also reduced the expression of genes related to fat synthesis and inflammation in adipose and hepatic cells, compared with the corresponding gene expression in the control group. These results indicate that L. rhamnosus 4B15 combined with hydrolysed lactose skim milk powder exerts anti-obesity effects by downregulating fat synthesis and inflammation. (c) 2021 Elsevier Ltd. All rights reserved.
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생활과학대학 (식품영양학과)
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