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Stereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H-1 receptor antagonist clemastine

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dc.contributor.authorJung, Jung Wha-
dc.contributor.authorKim, Hee-Doo-
dc.date.available2021-02-22T15:01:41Z-
dc.date.issued2007-12-
dc.identifier.issn0253-6269-
dc.identifier.issn1976-3786-
dc.identifier.urihttps://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14609-
dc.description.abstractHydroxyclemastine was targeted as a versatile analogue of clemastine with H-1 receptor antagonist activity. Stereoselective synthesis of (-)-hydroxyclemastine was performed in which the key step was chelation-controlled diastereoselective 1,2-addition of Grignard reagent to alpha-alkoxyketone.-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherPHARMACEUTICAL SOC KOREA-
dc.titleStereoselective synthesis of (-)-hydroxyclemastine as a versatile intermediate for the H-1 receptor antagonist clemastine-
dc.typeArticle-
dc.publisher.location대한민국-
dc.identifier.doi10.1007/BF02977320-
dc.identifier.scopusid2-s2.0-38049178761-
dc.identifier.wosid000252021000005-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.30, no.12, pp 1521 - 1525-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume30-
dc.citation.number12-
dc.citation.startPage1521-
dc.citation.endPage1525-
dc.type.docTypeArticle-
dc.identifier.kciidART001208380-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.subject.keywordPlusSELECTIVITY-
dc.subject.keywordAuthorhydroxyclemastine-
dc.subject.keywordAuthorclemastine-
dc.subject.keywordAuthorH-1 receptor antagonist-
dc.subject.keywordAuthorchelation-
dc.subject.keywordAuthorstereoselective-
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