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Effects of diarylheptanoids on the tumor necrosis factor-alpha-induced expression of adhesion molecules in human umbilical vein endothelial cells

Authors
Han, Jong-MinLee, Woo SongKim, Ju-RyoungSon, JoonsokNam, Ki-HoanChoi, Seung-ChulLim, Jong-SeokJeong, Tae-Sook
Issue Date
14-Nov-2007
Publisher
AMER CHEMICAL SOC
Keywords
diarylheptan.olds; 5-o-methylhirsutanonol; oregonin; HUVECs; VCAM-1; ICAM-1; inflammation; atherosclerosis
Citation
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, v.55, no.23, pp.9457 - 9464
Journal Title
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume
55
Number
23
Start Page
9457
End Page
9464
URI
https://scholarworks.sookmyung.ac.kr/handle/2020.sw.sookmyung/14612
DOI
10.1021/jf072157h
ISSN
0021-8561
Abstract
Atherosclerosis is a chronic inflammatory disease that is characterized by infiltration of mononuclear lymphocytes into the intima through the expression of adhesion molecules on the arterial wall. In the present study, we report the inhibitory effects of two diarylheptanoids, 5-O-methylhirsutanonol (1) and oregonin (2), isolated from the methanolic extracts of Alnus japonica leaves, on the expression of adhesion molecules in human umbilical vein enclothelial cells (HUVECs). Compounds 1 and 2 inhibited tumor necrosis factor (TNF)-alpha-induced up-regulation of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1), Which also prevented adhesion of monocytes to HUVECs, and slightly suppressed the mRNA expression of the inflammation-associated gene interleukin-1 beta (IL-1 beta). A further study demonstrated the inhibitory effect of compound 1 on DNA-binding of nuclear factor KB (NF-KB) and on the phosphorylation and degradation of inhibitory factor KB alpha (lKB alpha) in TNF-alpha-stimulated HUVECs. These results indicate that compounds 1 and 2 may be useful in the prevention and treatment of atherosclerosis through attenuation of adhesion molecule expression by inhibition of NF-KB activation.
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